@article{uoadl:3023556,
    volume = "29",
    number = "7-8",
    pages = "611-620",
    journal = "European Journal of Medicinal Chemistry",
    issn = "0223-5234",
    keywords = "1 benzyl 5 (3 methylphenyl) 3 (2 pyrazinyl) 1h 1,2,4 triazole;  1 benzyl 5 (4 methylphenyl) 3 (2 pyrazinyl) 1h 1,2,4 triazole;  1,2,4 triazole derivative;  1[(2 hydroxyethoxy)methyl] 5 (3 methylphenyl) 3 (2 pyrazinyl) 1h 1,2,4 triazole;  1[(2 hydroxyethoxy)methyl] 5 phenyl 3 (2 pyrazinyl) 1h 1,2,4 triazole;  3 deazaaristeromycin;  5 (2 bromovinyl) 2' deoxyuridine;  9 (2,3 dihydroxypropyl)adenine;  antivirus agent;  ribavirin;  unclassified drug, animal cell;  antiviral activity;  article;  controlled study;  cytotoxicity;  dna virus;  drug synthesis;  minimum inhibitory concentration;  nonhuman;  rna virus;  vero cell",
    BIBTEX_ENTRY = "article",
    year = "1994",
    author = "Todoulou, O. and Papadaki-Valiraki, A. and Ikeda, S. and De Clercq, E.",
    abstract = "A series of new 1H-1,2,4-triazole derivatives was synthesised and evaluated in vitro for activity against various DNA and RNA viruses. Compounds 1-benzyl-5-(4-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole 2b, 1-benzyl-5-(3-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole 2c and 1-[(2-hydroxyethoxy)methyl]-5-(3-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole 4h proved active against reovirus-1, and compounds 1-[(2-hydroxyethoxy)methyl]-5-phenyl-3-(2-pyrazinyl)-1H-1,2,4-triazole 4f and 1-[(2-hydroxyethoxy)methyl]-5-(3-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole 4h against parainfluenza-3 virus, in Vero cells at concentrations that were 5- to 40-fold lower than the cytotoxic concentration required to alter normal cell morphology. © 1994.",
    title = "Synthesis and antiviral activity of some new 1H-1,2,4-triazole derivatives",
    doi = "10.1016/0223-5234(94)90152-X"
}