@article{uoadl:3053514,
    volume = "16",
    number = "9",
    pages = "845-855",
    journal = "AIDS Research and Human Retroviruses",
    issn = "0889-2229, 1931-8405",
    BIBTEX_ENTRY = "article",
    year = "2000",
    author = "Paraskevis, D and Magiorkinis, M and Paparizos, V and Pavlakis, GN and and Hatzakis, A",
    abstract = "Recombination is one of several factors contributing to the genetic
diversity of HIV-1, which is divided into group M (itself comprising 11
subtypes, A-K) and two other groups named O and N, In the present study,
the full-length genome of an HIV-1 isolate obtained from a Greek subject
(GR17) infected in the Democratic Republic of the Congo (formerly Zaire)
was analyzed to reveal a novel mosaic sequence composed of subtypes A,
G, and E and regions of indeterminate classification, In particular,
most of pol and tat/vpu, as well as the region encoding intracellular
domain of gp41, did not cluster with any of the previously characterized
HIV-1 subtypes, The clustering of the LTR of GR17 with subtype E was
suggestive of a subtype E origin of the unclassified regions. However,
the identification of distinct characteristics in the LTR, such as two
functional NF-kappa B sites and a distinct TAR element, compared with
those of circulating (A/E) recombinants, suggests that the partial
subtype E sequences found in GR17 and the mosaic viruses (A/E) have not
derived from each other, These results provide evidence that parental
subtype E may have existed in the geographic area of Central Africa.",
    title = "Molecular characterization of a recombinant HIV type 1 isolate
(A/G/E/?): Unidentified regions may be derived from parental subtype E
sequences",
    doi = "10.1089/08892220050042783"
}