@article{uoadl:3067223,
    volume = "22",
    number = "10",
    pages = "1826-1838",
    journal = "Journal of The American Society for Mass Spectrometry",
    issn = "1044-0305, 1879-1123",
    keywords = "3,4-Dichloroaniline;  Atmospheric pressure chemical ionization;  DOE (design of experiments);  Electrosprays;  Matrix effects;  Optimization strategy;  Phenylureas;  Solvent effect;  Triazines, Acetonitrile;  Anoxic sediments;  Atmospheric chemistry;  Atmospheric pressure;  Degradation;  Design of experiments;  Electrospray ionization;  Herbicides;  Ion sources;  Ionization;  Ions;  Optimization;  Purification;  Seawater;  Sedimentology;  Shellfish;  Solvent extraction;  Solvents;  Submarine geology;  Urea, Atmospheric ionization, 2 tert butylamino 4 cyclopropylamino 6 methylthio 1,3,5 triazine;  diuron;  water, article;  case study;  chemical analysis;  chemical structure;  controlled study;  electrospray mass spectrometry;  environmental monitoring;  Greece;  intermethod comparison;  ionization;  limit of detection;  liquid chromatography;  mass spectrometry;  mussel;  process optimization;  proton transport;  sediment, Animals;  Bivalvia;  Chromatography, Liquid;  Diuron;  Geologic Sediments;  Reproducibility of Results;  Seawater;  Sensitivity and Specificity;  Spectrometry, Mass, Electrospray Ionization;  Tandem Mass Spectrometry;  Triazines;  Water Pollutants, Chemical",
    BIBTEX_ENTRY = "article",
    year = "2011",
    author = "Maragou, N.C. and Thomaidis, N.S. and Koupparis, M.A.",
    abstract = "A systematic and detailed optimization strategy for the development of atmospheric pressure ionization (API) LC-MS/MS methods for the determination of Irgarol 1051, Diuron, and their degradation products (M1, DCPMU, DCPU, and DCA) in water, sediment, and mussel is described. Experimental design was applied for the optimization of the ion sources parameters. Comparison of ESI and APCI was performed in positive-and negative-ion mode, and the effect of the mobile phase on ionization was studied for both techniques. Special attention was drawn to the ionization of DCA, which presents particular difficulty in API techniques. Satisfactory ionization of this small molecule is achieved only with ESI positive-ion mode using acetonitrile in the mobile phase; the instrumental detection limit is 0.11 ng/mL. Signal suppression was qualitatively estimated by using purified and non-purified samples. The sample preparation for sediments and mussels is direct and simple, comprising only solvent extraction. Mean recoveries ranged from 71% to 110%, and the corresponding (%) RSDs ranged between 4.1 and 14%. The method limits of detection ranged between 0.6 and 3.5 ng/g for sediment and mussel and from 1.3 to 1.8 ng/L for sea water. The method was applied to sea water, marine sediment, and mussels, which were obtained from marinas in Attiki, Greece. Ion ratio confirmation was used for the identification of the compounds. © American Society for Mass Spectrometry, 2011.",
    title = "Optimization and comparison of ESI and APCI LC-MS/MS methods: A case study of Irgarol 1051, Diuron, and their degradation products in environmental samples",
    doi = "10.1007/S13361-011-0191-Z"
}