@article{uoadl:3153154,
    volume = "129",
    number = "4",
    pages = "943-U421",
    journal = "Allergy: European Journal of Allergy and Clinical Immunology",
    keywords = "Allergy; Mechanisms of the Development of Allergy; Seventh Framework
Program; phenotypes; IgE; asthma",
    BIBTEX_ENTRY = "article",
    year = "2012",
    author = "Anto, Josep M. and Pinart, Mariona and Akdis, Muebeccel and Auffray, and Charles and Bachert, Claus and Basagana, Xavier and Carlsen, Kai-Hakon and and Guerra, Stefano and von Hertzen, Leena and Illi, Sabina and and Kauffmann, Francine and Keil, Thomas and Kiley, James P. and Koppelman, and Gerard H. and Lupinek, Christian and Martinez, Fernando D. and Nawijn, and Martijn C. and Postma, Dirkje S. and Siroux, Valerie and Smit, Henriette and A. and Sterk, Peter J. and Sunyer, Jordi and Valenta, Rudolf and and Valverde, Sergio and Akdis, Cezmi A. and Annesi-Maesano, Isabella and and Ballester, Ferran and Benet, Marta and Cambon-Thomsen, Anne and Chatzi, and Leda and Coquet, Jonathan and Demoly, Pascal and Gan, Weiniu and and Garcia-Aymerich, Judith and Gimeno-Santos, Elena and Guihenneuc-Jouyaux, and Chantal and Haahtela, Tari and Heinrich, Joachim and Herr, Marie and and Hohmann, Cynthia and Jacquemin, Benedicte and Just, Jocelyne and and Kerkhof, Marjan and Kogevinas, Manolis and Kowalski, Marek L. and and Lambrecht, Bart N. and Lau, Susanne and Carlsen, Karin C. Lodrup and and Maier, Dieter and Momas, Isabelle and Noel, Patricia and Oddie, Sam and and Palkonen, Susanna and Pin, Isabelle and Porta, Daniela and Punturieri, and Antonello and Ranciere, Fanny and Smith, Robert A. and Stanic, Barbara and and Stein, Renato T. and van de Veen, Willem and van Oosterhout, Antoon and J. M. and Varraso, Raphaelle and Wickman, Magnus and Wijmenga, Cisca and and Wright, John and Yaman, Gorkem and Zuberbier, Torsten and Bousquet, Jean and and WHO Collaborating Ctr Asthma",
    abstract = "Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework
Program European Union project, aims to generate novel knowledge on the
mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated
allergic diseases will be defined in MeDALL. As part of MeDALL, a
scientific seminar was held on January 24, 2011, to review current
knowledge on the IgE-related phenotypes and to explore how a
multidisciplinary effort could result in a new integrative translational
approach. This article provides a summary of the meeting. It develops
challenges in IgE-related phenotypes and new clinical and epidemiologic
approaches to the investigation of allergic phenotypes, including
cluster analysis, scale-free models, candidate biomarkers, and IgE
microarrays; the particular case of severe asthma was reviewed. Then
novel approaches to the IgE-associated phenotypes are reviewed from the
individual mechanisms to the systems, including epigenetics, human in
vitro immunology, systems biology, and animal models. The last chapter
deals with the understanding of the population-based IgE-associated
phenotypes in children and adolescents, including age effect in terms of
maturation, observed effects of early-life exposures and shift of focus
from early life to pregnancy, gene-environment interactions, cohort
effects, and time trends in patients with allergic diseases. This review
helps to define phenotypes of allergic diseases in MeDALL. (J Allergy
Clin Immunol 2012;129:943-54.)",
    title = "Understanding the complexity of IgE-related phenotypes from childhood to
young adulthood: A Mechanisms of the Development of Allergy (MeDALL)
Seminar",
    doi = "10.1016/J.JACI.2012.01.047"
}