@article{uoadl:3494135,
    volume = "46",
    number = "4",
    pages = "1541 – 1553",
    journal = "Neurological Sciences",
    issn = "1590-1874, 1590-3478",
    keywords = "Humans; Immunologic Factors; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Natalizumab; Oligoclonal Bands; immunoglobulin G; natalizumab; oligoclonal band; immunologic factor; natalizumab; oligoclonal band; adult; cerebrospinal fluid; disease duration; female; follow up; human; laboratory test; longitudinal study; male; meta analysis; Newcastle-Ottawa scale; outlier detection; practice guideline; quality control; relapsing remitting multiple sclerosis; Review; sensitivity analysis; systematic review; treatment duration; cerebrospinal fluid; drug therapy; multiple sclerosis; relapsing remitting multiple sclerosis",
    BIBTEX_ENTRY = "article",
    year = "2025",
    author = "Liampas, Andreas and Tseriotis, Vasilis-Spyridon and Mavridis, Theodoros and Vavougios, George D. and Zis, Panagiotis and Hadjigeorgiou, Georgios M. and Bargiotas, Panagiotis and Pourzitaki, Chryssa and Artemiadis, Artemios",
    abstract = "Introduction: Oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) are utilized for diagnosing multiple sclerosis (MS), as they are found in 95% of patients. Additionally, OCBs are linked to disease prognosis. The primary contributors to OCB production are long-lived plasma cells. This study aims to quantify the impact of natalizumab (NTZ) on OCB levels in the CSF of MS patients. Methods: A systematic search on MEDLINE, SCOPUS and Web of Science for English-written and peer-reviewed longitudinal studies on adults was performed. Methodological quality was assessed with the Newcastle–Ottawa Scale. Proportional meta-analysis was performed in R using a generalized linear mixed-effects model. We investigated heterogeneity with influence diagnostics, sensitivity analysis and meta-regression. Results: Eight eligible studies of adequate quality with a total sample of 326 relapsing–remitting MS patients were included. A summary rate of 14.07% [95% CI, 4.48%—36.36%] for complete loss of OCBs and 42.02% [95% CI, 15.23%—74.51%] for reduction in OCB number or intensity was observed, both with considerable heterogeneity. Pooled estimates dropped (11% [95% CI, 0.04%—0.29%] and 34% [95% CI, 0.11%—0.68%] respectively) after the identification of an influential study. Multivariable meta-regression identified IgG index as a factor contributing to heterogeneity (adj. p = 0.0279), regarding reduction of OCB number or intensity. Discussion: In conclusion, our systematic review and meta-analysis showed that NTZ can lead to reduction of intrathecal OCBs in MS patients, indicating a possible effect of NTZ on memory plasma cells, which are the main source of OCBs in MS. © Fondazione Società Italiana di Neurologia 2024.",
    title = "Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of patients with multiple sclerosis: a systematic review and meta-analysis",
    doi = "10.1007/S10072-024-07930-W"
}