@article{2956672,
    title = "Efforts to understand the molecular basis of hypertension through drug:membrane interactions",
    author = "T Mavromoustakos and P Zoumpoulakis and I Kyrikou and A Zoga and E Siapi and M Zervou and I Daliani and D Dimitriou and A Pitsas and C Kamoutsis and P Laggner",
    journal = "Current Topics in Medicinal Chemistry",
    year = "2004",
    volume = "4",
    number = "4",
    pages = "445-59",
    publisher = "Bentham Science Publishers Ltd",
    issn = "1568-0266",
    doi = "10.2174/1568026043451339",
    keywords = "-",
    abstract = "Biological membranes play an essential role in the drug action. They constitute the first barrier for drugs to exert their biological action. AT1 antagonists are amphiphilic molecules and are hypothesized to act on AT1 receptor through incorporation (first step) and lateral diffusion through membrane bilayers (second step). Various biophysical methods along with Molecular Modelling were applied in order to explore the plausible two step proposed mechanism of action for this class of antihypertensive drugs."
}