@article{2956949,
    title = "Synthesis of new optically active 2-pyrrolidinones.",
    author = "P.M. Minakakis, E. Papavassilopoulou, T. Mavromoustakos",
    journal = "Molecules",
    year = "2013",
    volume = "18",
    number = "1",
    pages = "50-73",
    publisher = "Elsevier",
    issn = "1420-3049",
    doi = "10.3390/molecules18010050",
    keywords = "S-pyroglutamic acid; 2-pyrrolidinone; imidazole",
    abstract = "A new class of optically active 2-pyrrolidinones was synthesized, starting from 
S-pyroglutamic acid, a well known natural chiral synthon. The synthetic design followed 
led to the insertion of various substituents at positions 1 and 5 of the 2-pyrrolidinone ring, 
including the imidazole moiety. Some of them possess two or three stereogenic centers, the 
configuration of which was retained under the mild conditions used. The new compounds 
also carry an imidazole moiety, which, along with the 2-pyrrolidinone template, may prove 
pivotal to several biological processes"
}