@article{2956983,
    title = "An efficient synthetic method and theoretical calculations of olmesartan methyl ether: Study of biological function of AT1 antagonism",
    author = "D. Ntountaniotis, G. Agelis, A. Resvani, M. Halabalaki, G. Liapakis, K. Spyridaki,  S. Golic Grdadolnik, F. Merzel, S. Kostidis, C. Potamitis, T. Tselios, J. Matsoukas, A. L. Skaltsounis,  T.  Mavromoustakos",
    journal = "Combinatorial Chemistry & High Throughput Screening",
    year = "2014",
    volume = "17",
    number = "8",
    pages = "652-662",
    publisher = "Bentham Science Publishers",
    issn = "1386-2073",
    doi = "10.2174/138620731708140922171503",
    keywords = "Angiotensin II AT1 receptor blocker, drug discovery, ethers, NMR, olmesartan, synthetic method, theoretical  calculations.",
    abstract = "The dissolution of the antihypertensive AT1 antagonist olmesartan in methanol generates in situ a new highly 
bioactive methyl ether analogue via SN1 mechanism involving an intramolecular proton transfer from carboxyl to 
hydroxyl group. Theoretical calculations confirmed the thermodynamic control preference of methyl ether versus the 
antagonistic product methyl ester. Α facile synthetic method for olmesartan methyl ether from olmesartan or olmesartan 
medoxomil is also described. Interestingly, the introduction of the methyl group to olmesartan did not alter its 
pharmacological properties. This observation opens new avenues in the synthesis of novel drugs, since hydroxyl and 
carboxylate groups have an orthogonal relationship in many drugs."
}