@article{2976817,
    title = "Seroepidemiological study of pandemic influenza H1N1 following the 2009-2010 wave in Greece",
    author = "Maltezou, H.C. and Katerelos, P. and Mavrouli, M. and Lourida, A. and Routsias, J.G. and Spanakis, N. and Maragos, A. and Tedoma, A. and Bassiakos, Y. and Koratzanis, G. and Mantagos, S. and Metallidis, S. and Katragkou, A. and Nikolaidis, P. and Roilides, E. and Theodoridou, M. and Tsakris, A.",
    journal = "Vaccine",
    year = "2011",
    volume = "29",
    number = "38",
    pages = "6664-6669",
    issn = "0264-410X",
    doi = "10.1016/j.vaccine.2011.06.098",
    keywords = "adolescent;  adult;  article;  child;  geographic distribution;  Greece;  human;  infant;  infection risk;  influenza A (H1N1);  Influenza virus A H1N1;  major clinical study;  pandemic influenza;  priority journal;  risk assessment;  risk factor;  seroepidemiology;  seroprevalence, Adolescent;  Adult;  Age Distribution;  Aged;  Aged, 80 and over;  Antibodies, Viral;  Child;  Child, Preschool;  Enzyme-Linked Immunosorbent Assay;  Female;  Geography;  Greece;  Humans;  Infant;  Infant, Newborn;  Influenza A Virus, H1N1 Subtype;  Influenza, Human;  Male;  Middle Aged;  Seroepidemiologic Studies;  Young Adult",
    abstract = "Knowledge of seroprevalence rates against 2009 pandemic H1N1 virus will assist vaccination recommendations and the preparation of the health-care system during subsequent years. This study was conducted in Greece during June-August 2010 to estimate the seroprevalence rate against pandemic H1N1 virus. Persons presenting in 29 health-care facilities across the country were studied. Seroprevalence was estimated employing a virus-free ELISA that specifically recognizes 2009 H1N1 virus antibodies in human sera. Sera collected from 2005 to April 2009 were also used to estimate pre-pandemic seroprevalence rates. A total of 954 persons were studied. The overall seroprevalence rate was 28.5% (95% confidence interval =25.6-31.3%). Age-specific rates were 34.2% in persons 0-4 years, 36.3% in persons 5-19 years, 25.0% in persons 20-39 years, 23.4% in persons 40-59 years, and 31.8% in persons ≥60 years. The highest rates were recorded in the Regions of Ionian Islands (67%) and Epirus (42.9%), while the lowest (8.4%) in the Region of Thessaly. Age-specific attack rates of infection during 2009-2010 were 28.8% in persons 0-4 years, 32.5% in persons 5-19 years, 14.3% in persons 20-39 years, 19.1% in persons 40-59 years, and 14.4% in persons ≥60 years. Multivariate analysis revealed that Region of residence and caring for children <5 years were associated with increased risk for seropositivity. Urbanity, personal and family characteristics, working in a health-care facility or in a school, history of pandemic H1N1 vaccination or history of influenza-like illness during 2009-2010 were not associated with increased risk for seropositivity. © 2011 Elsevier Ltd."
}