@article{2981672,
    title = "Effect of dobutamine combined with intra-aortic balloon counterpulsation on left ventricular function early after acute myocardial infarction: Experimental study",
    author = "Toumanidis, S.T. and Tsirikos Karapanos, N. and Kottis, G. and Kaladaridou, A. and Bramos, D. and Trikka, C.O. and Vasiladiotis, N. and Zakopoulos, N. and Moulopoulos, S.D.",
    journal = "Artificial Organs",
    year = "2011",
    volume = "35",
    number = "9",
    pages = "875-882",
    issn = "0160-564X, 1525-1594",
    doi = "10.1111/j.1525-1594.2011.01327.x",
    keywords = "Balloons;  Cardiology;  Echocardiography, Acute myocardial infarction;  Counterpulsation;  Dobutamine;  Ejection fraction;  Intra-aortic balloon pumping;  LEft anterior descending arteries;  Left ventricular function;  Left ventricular remodeling;  Measurements of;  Myocardial Infarction, Blood vessels, dobutamine, acute heart infarction;  animal experiment;  animal model;  aorta balloon;  artery ligation;  article;  cardiovascular parameters;  comparative effectiveness;  counterpulsation;  drug effect;  echocardiography;  experimental study;  fractional shortening;  heart ejection fraction;  heart left ventricle function;  heart output;  heart stroke volume;  intermethod comparison;  left anterior descending coronary artery;  nonhuman;  priority journal, Suidae",
    abstract = "Acute myocardial infarction (AMI) causes left ventricular (LV) remodeling, which forms the substrate for its early and late complications. The purpose of this study was to compare the acute effect of dobutamine or intra-aortic balloon pumping (IABP), alone or in combination, on LV function in the early phase of an experimental AMI. In 18 pigs, AMI was induced by ligation of the left anterior descending artery (LAD). IABP or dobutamine infusion at a rate of 5μg/kg/min, or a combination of the two, was applied immediately after ligation of the LAD. Echocardiographic measurements of the long and short LV axes were obtained before (baseline) and post LAD ligation and at the end of each intervention for 5, 15, and 30min. The fractional shortening (FS) of both axes, as well as the ejection fraction (EF), was calculated. The combination of dobutamine with IABP increased the EF significantly after the AMI in comparison to dobutamine or IABP alone, and improved the stroke volume, cardiac output, and long axis FS in comparison to IABP alone. Dobutamine alone produced a significantly higher increase of EF in comparison to IABP alone. These results indicate that the combination of dobutamine with IABP may be useful during AMI. © 2011, the Authors. Artificial Organs © 2011, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc."
}