@article{2982638, title = "Neuroscience20 (BRAIN20, SPINE20, and MENTAL20) Health Initiative: A Global Consortium Addressing the Human and Economic Burden of Brain, Spine, and Mental Disorders through Neurotech Innovations and Policies", author = "Morris, K. and Nami, M. and Bolanos, J.F. and Lobo, M.A. and Sadri-Naini, M. and Fiallos, J. and Sanchez, G.E. and Bustos, T. and Chintam, N. and Amaya, M. and Strand, S.E. and Mayuku-Dore, A. and Sakibova, I. and Biso, G.M.N. and Defilippis, A. and Bravo, D. and Tarhan, N. and Claussen, C. and Mercado, A. and Braun, S. and Yuge, L. and Okabe, S. and Taghizadeh-Hesary, F. and Kotliar, K. and Sadowsky, C. and Chandra, P.S. and Tripathi, M. and Katsaros, V. and Mehling, B. and Noroozian, M. and Abbasioun, K. and Amirjamshidi, A. and Hossein-Zadeh, G.-A. and Naraghi, F. and Barzegar, M. and Asadi-Pooya, A.A. and Sahab-Negah, S. and Sadeghian, S. and Fahnestock, M. and DIlbaz, N. and Hussain, N. and Mari, Z. and Thatcher, R.W. and Sipple, D. and Sidhu, K. and Chopra, D. and Costa, F. and Spena, G. and Berger, T. and Zelinsky, D. and Wheeler, C.J. and Ashford, J.W. and Schulte, R. and Nezami, M.A. and Kloor, H. and Filler, A. and Eliashiv, D.S. and Sinha, D. and Desalles, A.A.F. and Sadanand, V. and Suchkov, S. and Green, K. and Metin, B. and Hariri, R. and Cormier, J. and Yamamoto, V. and Kateb, B.", journal = "Journal of Alzheimer's Disease", year = "2021", volume = "83", number = "4", pages = "1563-1601", publisher = "IOS Press BV", issn = "1387-2877, 1875-8908", doi = "10.3233/JAD-215190", keywords = "Africa; Africa south of the Sahara; Alzheimer disease; amyotrophic lateral sclerosis; Asia; Australia; awareness; brain disease; brain mapping; central nervous system cancer; clinical outcome; cooperation; coronavirus disease 2019; dementia; developing country; European Union; global disease burden; health care cost; health care policy; human; investment; medical society; medical technology; mental disease; multiple sclerosis; neurologic disease; neuroscience; North America; photonics; Review; South and Central America; spine disease; United States; economics; global health; international cooperation; mental disease; neurologic disease; neuroscience; organization and management; procedures, COVID-19; Global Burden of Disease; Global Health; Humans; International Cooperation; Mental Disorders; Nervous System Diseases; Neurosciences; SARS-CoV-2", abstract = "Neurological disorders significantly impact the world's economy due to their often chronic and life-threatening nature afflicting individuals which, in turn, creates a global disease burden. The Group of Twenty (G20) member nations, which represent the largest economies globally, should come together to formulate a plan on how to overcome this burden. The Neuroscience-20 (N20) initiative of the Society for Brain Mapping and Therapeutics (SBMT) is at the vanguard of this global collaboration to comprehensively raise awareness about brain, spine, and mental disorders worldwide. This paper aims to provide a comprehensive review of the various brain initiatives worldwide and highlight the need for cooperation and recommend ways to bring down costs associated with the discovery and treatment of neurological disorders. Our systematic search revealed that the cost of neurological and psychiatric disorders to the world economy by 2030 is roughly $16T. The cost to the economy of the United States is $1.5T annually and growing given the impact of COVID-19. We also discovered there is a shortfall of effective collaboration between nations and a lack of resources in developing countries. Current statistical analyses on the cost of neurological disorders to the world economy strongly suggest that there is a great need for investment in neurotechnology and innovation or fast-tracking therapeutics and diagnostics to curb these costs. During the current COVID-19 pandemic, SBMT, through this paper, intends to showcase the importance of worldwide collaborations to reduce the population's economic and health burden, specifically regarding neurological/brain, spine, and mental disorders. © 2021 - IOS Press. All rights reserved." }