@article{2984332,
    title = "Slight and short-lasting increase of serum S-100B protein in extra-cranial trauma",
    author = "Korfias, S. and Stranjalis, G. and Psachoulia, C. and Vasiliadis, C. and Pitaridis, M. and Boviatsis, E. and Sakas, D.E.",
    journal = "Brain Injury Journey Magazine",
    year = "2006",
    volume = "20",
    number = "8",
    pages = "867-872",
    publisher = "Informa Healthcare",
    doi = "10.1080/02699050600832395",
    keywords = "biological marker;  protein S100B, abdominal injury;  adult;  aged;  article;  controlled study;  correlation analysis;  female;  fracture;  human;  injury severity;  major clinical study;  male;  postoperative period;  protein blood level;  protein secretion;  rank sum test;  surgical injury;  thorax injury;  traumatic brain injury;  Wilcoxon signed ranks test",
    abstract = "Objective: Serum S-100B protein is an established biochemical marker of traumatic brain injury. At the same time, the question of extra-cranial S-100B release has been raised. This study evaluates the post-traumatic and post-operative release kinetics of S-100B in 45 trauma victims without head injury. Method: Serum S-100B protein was measured on admission and every 24 hours for 4 consecutive days. Results: Initial S-100B was slightly increased (median: 0.54 μg L-1) and correlated with the severity of extra-cranial trauma (p = 0.0004, Mann-Whitney test). Both severely (abdominal or chest trauma with or without bone fractures) and mildly (long bone fractures) injured showed a rapid decline of S-100B (<0.2 μg L-1) around 72 hours post-trauma. Extra-cranial surgery caused a secondary increase of S-100B, especially in the mildly injured group (p = 0.004, Wilcoxon signed rankest). Conclusions: Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury)."
}