@article{2984918,
    title = "Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection",
    author = "Saccone, G. and Sen, C. and Di Mascio, D. and Galindo, A. and Grünebaum, A. and Yoshimatsu, J. and Stanojevic, M. and Kurjak, A. and Chervenak, F. and Suárez, M.J.R. and Gambacorti-Passerini, Z.M. and de los Angeles Anaya Baz, M. and Galán, E.V.A. and López, Y.C. and Luis, J.A.D.L. and Hernández, I.C. and Herraiz, I. and Villalain, C. and Venturella, R. and Rizzo, G. and Mappa, I. and Gerosolima, G. and Hellmeyer, L. and Königbauer, J. and Ameli, G. and Frusca, T. and Volpe, N. and Schera, G.B.L. and Fieni, S. and Esposito, E. and Simonazzi, G. and Di Donna, G. and Youssef, A. and Gatta, A.N.D. and Di Donna, M.C. and Chiantera, V. and Buono, N. and Sozzi, G. and Greco, P. and Morano, D. and Bianchi, B. and Marino, M.G.L. and Laraud, F. and Ramone, A. and Cagnacci, A. and Barra, F. and Gustavino, C. and Ferrero, S. and Ghezzi, F. and Cromi, A. and Laganà, A.S. and Longo, V.L. and Stollagli, F. and Sirico, A. and Lanzone, A. and Driul, L. and Cecchini, F. and Xodo, S. and Rodriguez, B. and Mercado-Olivares, F. and Elkafrawi, D. and Sisti, G. and Esposito, R. and Coviello, A. and Cerbone, M. and Morlando, M. and Schiattarella, A. and Colacurci, N. and De Franciscis, P. and Cataneo, I. and Lenzi, M. and Sandri, F. and Buscemi, R. and Gattei, G. and Sala, F.D. and Valori, E. and Rovellotti, M.C. and Done, E. and Faron, G. and Gucciardo, L. and Esposito, V. and Vena, F. and Giancotti, A. and Brunelli, R. and Muzii, L. and Nappi, L. and Sorrentino, F. and Liberati, M. and Buca, D. and Leombroni, M. and Di Sebastiano, F. and Franchi, M. and Ianniciello, Q.C. and Garzon, S. and Petriglia, G. and Borrello, L. and Nieto-Calvache, A.J. and Burgos-Luna, J.M. and Kadji, C. and Carlin, A. and Bevilacqua, E. and Moucho, M. and Viana Pinto, P. and Figueiredo, R. and Morales Roselló, J. and Loscalzo, G. and Martinez-Varea, A. and Diago, V. and Jimenez Lopez, J.S. and Aykanat, A.Y. and Cosma, S. and Carosso, A. and Benedetto, C. and Bermejo, A. and Feuerschuette, O.H.M. and Uyaniklar, O. and Ocakouglu, S.R. and Atak, Z. and Gündüz, R. and Haberal, E.T. and Froessler, B. and Parange, A. and Palm, P. and Samardjiski, I. and Taccaliti, C. and Okuyan, E. and Daskalakis, G. and de Sa, R.A.M. and Pittaro, A. and Gonzalez-Duran, M.L. and Guisan, A.C. and Genç, S.Ö. and Zlatohlávková, B. and Piqueras, A.L. and Oliva, D.E. and Cil, A.P. and Api, O. and Antsaklis, P. and Ples, L. and Kyvernitakis, I. and Maul, H. and Malan, M. and Lila, A. and Granese, R. and Ercoli, A. and Zoccali, G. and Villasco, A. and Biglia, N. and Madalina, C. and Costa, E. and Daelemans, C. and Pintiaux, A. and Cueto, E. and Hadar, E. and Dollinger, S. and Brzezinski-Sinai, N.A. and Huertas, E. and Arango, P. and Sanchez, A. and Schvartzman, J.A. and Cojocaru, L. and Turan, S. and Turan, O. and Di Dedda, M.C. and Molpeceres, R.G. and Zdjelar, S. and Premru-Srsen, T. and Kornhauser-Cerar, L. and Druškovic, M. and De Robertis, V. and Stefanovic, V. and Nupponen, I. and Nelskylä, K. and Khodjaeva, Z. and Gorina, K.A. and Sukhikh, G.T. and Maruotti, G.M. and Visentin, S. and Cosmi, E. and Ferrari, J. and Gatti, A. and Luvero, D. and Angioli, R. and Puri, L. and Palumbo, M. and D'Urso, G. and Colaleo, F. and Rapisarda, A.M.C. and Carbone, I.F. and Manzoli, L. and Flacco, M.E. and Nazzaro, G. and Locci, M. and Guida, M. and Sardo, A.D.S. and Panici, P.B. and Khalil, A. and Berghella, V. and Bifulco, G. and Scambia, G. and Zullo, F. and D'Antonio, F. and The WAPM (World Association of Perinatal Medicine) Working Group on COVID-19",
    journal = "Ultrasound in Obstetrics and Gynecology",
    year = "2021",
    volume = "57",
    number = "2",
    pages = "232-241",
    publisher = "John Wiley and Sons Ltd",
    issn = "0960-7692, 1469-0705",
    doi = "10.1002/uog.23107",
    keywords = "adult;  artificial ventilation;  cohort analysis;  diagnosis;  female;  genetics;  hospitalization;  human;  infant;  intensive care unit;  isolation and purification;  maternal mortality;  mortality;  newborn;  pandemic;  pregnancy;  pregnancy complication;  pregnancy outcome;  retrospective study;  virology, Adult;  Cohort Studies;  COVID-19;  Female;  Hospitalization;  Humans;  Infant;  Infant, Newborn;  Intensive Care Units;  Maternal Mortality;  Pandemics;  Pregnancy;  Pregnancy Complications, Infectious;  Pregnancy Outcome;  Respiration, Artificial;  Retrospective Studies;  SARS-CoV-2",
    abstract = "Objectives: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. © 2020 International Society of Ultrasound in Obstetrics and Gynecology. © 2020 International Society of Ultrasound in Obstetrics and Gynecology"
}