@article{2987287, title = "The Mediterranean diet from past to future: Key concepts from the second “Ancel Keys” International Seminar", author = "Russo, G.L. and Siani, A. and Fogliano, V. and Geleijnse, J.M. and Giacco, R. and Giampaoli, S. and Iacoviello, L. and Kromhout, D. and Lionetti, L. and Naska, A. and Pellegrini, N. and Riccardi, G. and Sofi, F. and Vitale, M. and Strazzullo, P.", journal = "Nutrition, Metabolism and Cardiovascular Diseases", year = "2021", volume = "31", number = "3", pages = "717-732", publisher = "Elsevier B.V.", issn = "0939-4753", doi = "10.1016/j.numecd.2020.12.020", keywords = "alpha tocopherol; ascorbic acid; canola oil; inflammasome; interleukin 6; linoleic acid; low density lipoprotein cholesterol; monounsaturated fatty acid; oleic acid; polyphenol; reactive oxygen metabolite; saturated fatty acid; sugar, adult; aged; anxiety; apple; Article; atherosclerosis; atrial fibrillation; awards and prizes; awareness; behavior change; biodiversity; bioenergy; biotransformation; body mass; caloric intake; cancer risk; cardiovascular disease; cardiovascular mortality; cardiovascular risk; child; dairy product; degenerative disease; depression; diet; dietary compliance; dietary fiber; dietary intake; endoplasmic reticulum stress; energy expenditure; exercise; fat intake; feeding behavior; female; food industry; food intake; food safety; fruit; greenhouse gas; health promotion; healthy diet; human; hypertension; immigrant; industrialization; inflammation; inheritance; ischemic heart disease; Italy; life cycle assessment; life expectancy; lifestyle; lipid composition; lipid diet; lipid storage; male; meat; Mediterranean diet; mental disease; metabolomics; milk; mitochondrial biogenesis; mitochondrial dynamics; non insulin dependent diabetes mellitus; nutrition; obesity; oxidative stress; physical activity; potassium intake; premature mortality; prevalence; prophylaxis; questionnaire; randomized controlled trial (topic); risk factor; seasonal variation; secondary prevention; sodium intake; sugar intake; United Nations Educational, Scientific and Cultural Organization; vegetable; Western diet; whole grain; animal; chronic disease; evidence based medicine; nutritional status; nutritional value; protection; risk assessment; risk reduction, Animals; Chronic Disease; Diet, Healthy; Diet, Mediterranean; Evidence-Based Medicine; Humans; Nutritional Status; Nutritive Value; Protective Factors; Risk Assessment; Risk Factors; Risk Reduction Behavior", abstract = "The year 2020 celebrated the tenth anniversary of the recognition of the Mediterranean Diet as Intangible Cultural Heritage of Humanity by the UNESCO Intergovernmental Committee. This event represented a milestone in the history of nutrition, as the Mediterranean diet was the first traditional food practice to receive such award. Since then, a lot has been discussed not only on the beneficial aspects of the Mediterranean diet, but also on its complex role as a lifestyle model that includes a set of skills, knowledge and intercultural dialogue. This process ended up with the recognition in 2019 of Mediterranean diet as a possibly universal model of healthy diet from the EAT-Lancet Commission. These concepts were widely debated at the 2019 “Ancel Keys” International Seminar, held in Ascea (Italy) (for more information see: www.mediterraneandietseminar.org) with the aim to stimulate interest and awareness of a young group of participants on the current problems inherent to the effective implementation of the Mediterranean diet. The present article collects the contributions of several lecturers at the Seminar on key issues such as methodological and experimental approach, sustainability, molecular aspects in disease prevention, future exploitation, without neglecting a historical view of the Seven Countries Study. From the Seminar conclusions emerged a still vibrant and modern role of Mediterranean diet. The years to come will see national and international efforts to reduce the barriers that limit adherence to Mediterranean diet in order to plan for multi-factorial and targeted interventions that would guide our populations to a sustainable healthy living. © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University" }