@article{2987350,
    title = "Changes in stroke hospital care during the covid-19 pandemic: A systematic review and meta-analysis",
    author = "Katsanos, A.H. and Palaiodimou, L. and Zand, R. and Yaghi, S. and Kamel, H. and Navi, B.B. and Turc, G. and Benetou, V. and Sharma, V.K. and Mavridis, D. and Shahjouei, S. and Catanese, L. and Shoamanesh, A. and Vadikolias, K. and Tsioufis, K. and Lagiou, P. and Sfikakis, P.P. and Alexandrov, A.V. and Tsiodras, S. and Tsivgoulis, G.",
    journal = "ISRN Stroke",
    year = "2021",
    pages = "3651-3660",
    publisher = "Lippincott Williams and Wilkins",
    issn = "2090-9454",
    doi = "10.1161/STROKEAHA.121.034601",
    keywords = "brain ischemia;  cerebrovascular accident;  endovascular surgery;  fibrinolytic therapy;  health care delivery;  hospital mortality;  hospitalization;  human;  meta analysis;  odds ratio;  severity of illness index;  thrombectomy;  treatment outcome, COVID-19;  Delivery of Health Care;  Endovascular Procedures;  Hospital Mortality;  Hospitalization;  Humans;  Ischemic Stroke;  Odds Ratio;  SARS-CoV-2;  Severity of Illness Index;  Stroke;  Thrombectomy;  Thrombolytic Therapy;  Treatment Outcome",
    abstract = "BACKGROUND AND PURPOSE: We systematically evaluated the impact of the coronavirus 2019 (COVID-19) pandemic on stroke care across the world. METHODS: Observational studies comparing characteristics, acute treatment delivery, or hospitalization outcomes between patients with stroke admitted during the COVID-19 pandemic and those admitted before the pandemic were identified by Medline, Scopus, and Embase databases search. Random-effects meta-analyses were conducted for all outcomes. RESULTS: We identified 46 studies including 129 491 patients. Patients admitted with stroke during the COVID-19 pandemic were found to be younger (mean difference, -1.19 [95% CI, -2.05 to -0.32]; I2=70%) and more frequently male (odds ratio, 1.11 [95% CI, 1.01-1.22]; I2=54%) compared with patients admitted with stroke in the prepandemic era. Patients admitted with stroke during the COVID-19 pandemic, also, had higher baseline National Institutes of Health Stroke Scale scores (mean difference, 0.55 [95% CI, 0.12-0.98]; I2=90%), higher probability for large vessel occlusion presence (odds ratio, 1.63 [95% CI, 1.07-2.48]; I2=49%) and higher risk for in-hospital mortality (odds ratio, 1.26 [95% CI, 1.05-1.52]; I2=55%). Patients with acute ischemic stroke admitted during the COVID-19 pandemic had higher probability of receiving endovascular thrombectomy treatment (odds ratio, 1.24 [95% CI, 1.05-1.47]; I2=40%). No difference in the rates of intravenous thrombolysis administration or difference in time metrics regarding onset to treatment time for intravenous thrombolysis and onset to groin puncture time for endovascular thrombectomy were detected. CONCLUSIONS: The present systematic review and meta-analysis indicates an increased prevalence of younger patients, more severe strokes attributed to large vessel occlusion, and higher endovascular treatment rates during the COVID-19 pandemic. Patients admitted with stroke during the COVID-19 pandemic had higher in-hospital mortality. These findings need to be interpreted with caution in view of discrepant reports and heterogeneity being present across studies. © 2021 Lippincott Williams and Wilkins. All rights reserved."
}