@article{2988052,
    title = "Short-term effects of Mediterranean-type diet intervention on soluble cellular adhesion molecules in subjects with abdominal obesity",
    author = "Rallidis, L.S. and Kolomvotsou, A. and Lekakis, J. and Farajian, P. and Vamvakou, G. and Dagres, N. and Zolindaki, M. and Efstathiou, S. and Anastasiou-Nana, M. and Zampelas, A.",
    journal = "Clinical Nutrition ESPEN",
    year = "2017",
    volume = "17",
    pages = "38-43",
    publisher = "Elsevier Ireland Ltd",
    issn = "2405-4577",
    doi = "10.1016/j.clnesp.2016.11.002",
    keywords = "alcohol;  alpha tocopherol;  ascorbic acid;  beta carotene;  C reactive protein;  cell adhesion molecule;  cholesterol;  interleukin 6;  monounsaturated fatty acid;  polyunsaturated fatty acid;  saturated fatty acid;  soluble cell adhesion molecule;  soluble endothelial leukocyte adhesion molecule 1;  soluble intercellular adhesion molecule 1;  soluble vascular cell adhesion molecule 1;  unclassified drug;  autacoid;  biological marker;  cell adhesion molecule, abdominal obesity;  adult;  Article;  blood sampling;  body mass;  body weight;  caloric intake;  controlled study;  dietary fiber;  female;  human;  major clinical study;  male;  Mediterranean diet;  middle aged;  abdominal obesity;  blood;  diet therapy;  down regulation;  Greece;  nutritional status;  pathophysiology;  randomized controlled trial;  time factor;  treatment outcome, Adult;  Biomarkers;  Cell Adhesion Molecules;  Diet, Mediterranean;  Down-Regulation;  Female;  Greece;  Humans;  Inflammation Mediators;  Male;  Middle Aged;  Nutritional Status;  Obesity, Abdominal;  Time Factors;  Treatment Outcome",
    abstract = "Background & aims Abdominal obesity (AO) is associated with increased risk for cardiovascular disease and with increased production of adhesion molecules. The present work examined the effect of a Mediterranean-style diet on soluble cellular adhesion molecules in individuals with AO. Methods Ninety subjects with AO without cardiovascular disease or diabetes mellitus were randomly allocated to the intervention or control group and were instructed to follow a Mediterranean-style diet for two months. Intervention group followed a specific relevant food plan with close dietetic supervision and provision of basic foods. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), sP and sE-selectin, C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Results Subjects in the intervention group increased their intake of total fat, monounsaturated fatty acids, dietary fiber, vitamin C, and alcohol compared to controls, while decreased their intake of saturated fat. Although there was a significant decrease in CRP, sP-selectin and in sE-selectin in the intervention group, and an increase in sVCAM-1 in the control group, between-group analysis showed no statistically significant differences. There were also no significant changes in sICAM-1, and IL-6 levels after intervention. Conclusions Mediterranean-type diet for two months combined with close dietetic supervision showed a beneficial tendency towards the down-regulation of some markers of vascular inflammation, although the comparison between groups after the intervention did not reach statistical significance. A longer period of dietary intervention may be required to further support these changes. © 2016"
}