@article{2989939,
    title = "Tumors of the labial mucosa: A retrospective study of 1045 biopsies",
    author = "Kalogirou, E.-M. and Balta, M.G. and Koufatzidou, M. and Tosiou, A. and Tosios, K.I. and Nikitakis, N.G.",
    journal = "Medicine Oral: Patologia Oral y Cirugia Bucal",
    year = "2021",
    volume = "26",
    number = "1",
    pages = "e36-e42",
    publisher = "Medicina Oral S.L.",
    issn = "1698-4447, 1698-6946",
    doi = "10.4317/medoral.23933",
    keywords = "Article;  benign neoplasm;  cyst;  cystadenocarcinoma;  data analysis software;  female;  fibroma;  glomus tumor;  hemangioma;  histopathology;  human;  human tissue;  hyperplasia;  leiomyoma;  lip tumor;  lipoma;  lymphoma;  male;  mouth tumor;  mucosa;  myxoma;  neurilemoma;  retrospective study;  squamous cell carcinoma;  tumor localization;  tumor volume;  biopsy;  lip;  lip tumor;  mouth mucosa, Biopsy;  Humans;  Lip;  Lip Neoplasms;  Mouth Mucosa;  Retrospective Studies",
    abstract = "Background: To investigate the relative frequency of localized mucosal swellings of the upper and lower labial mucosa, the clinical-pathological diagnosis agreement and whether patient’s age and gender and tumor’s site and size may raise the suspicion of neoplasm. Material and Methods: Retrospective analysis was performed on upper or lower labial mucosal tumors, histopathologically diagnosed between 2009-2018. The diagnostic categories developmental/reactive tumors, benign and malignant neoplasms were associated with patient’s age and gender and tumor’s site and size; clinical-pathological diagnosis agreement was, also, evaluated. Results: Overall, 1000 (95.7%) developmental/reactive tumors, 35 (3.3%) benign and 10 (1%) malignant neoplasms were found. Upper/lower lip tumor ratio was 0.14:1. The diagnostic category was significantly associated with age (p<0.0001), site (p<0.0001) and diameter (p<0.0001). Age ≥60 years, tumor’s location on the upper lip and diameter >1cm were independent predictors for neoplasms. Patients presenting 2 or 3 of these variables were 20.2 times (p < 0.0001) or 33.6 times (p < 0.0001), respectively, more likely to have a neoplasm. Complete/partial agreement between clinical and pathological diagnosis was seen in 96.3% of the cases. Conclusions: Most lip tumors involve the lower lip and are reactive, but upper lip tumors measuring >1cm in patients≥ 60 years have significantly higher probability to be neoplasms. © Medicina Oral S. L. C.I.F."
}