@article{2990192,
    title = "Dietary intake and cholelithiasis: A review",
    author = "Kotrotsios, A. and Tasis, N. and Angelis, S. and Apostolopoulos, A.P. and Vlasis, K. and Papadopoulos, V. and Filippou, D.",
    journal = "Journal of Long-Term Effects of Medical Implants",
    year = "2019",
    volume = "29",
    number = "4",
    pages = "317-326",
    publisher = "Begell House, Inc",
    issn = "1050-6934",
    doi = "10.1615/JLongTermEffMedImplants.2020034732",
    keywords = "Biological organs;  Carbohydrates;  Cholesterol;  Fatty acids;  Nutrition;  Proteins, English languages;  Environmental factors;  Epidemiological studies;  Gastrointestinal disorders;  MEDLINE database;  Potential risks;  Systematic Review;  Western societies, Risks, alpha tocopherol;  cholesterol;  glucose;  high density lipoprotein cholesterol;  iron;  low density lipoprotein cholesterol;  monounsaturated fatty acid;  omega 3 fatty acid;  polyunsaturated fatty acid;  saturated fatty acid;  triacylglycerol;  vitamin D;  zinc, alcohol consumption;  body mass;  body weight loss;  carbohydrate intake;  cholecystectomy;  cholelithiasis;  cholesterol intake;  crystallization;  dietary fiber;  dietary intake;  dietary pattern;  fat intake;  fiber intake;  food composition;  food quality;  gallbladder function;  gallstone formation;  glycemic index;  healthy diet;  hospitalization;  human;  obesity;  pathogenesis;  prevalence;  protein intake;  Review;  risk assessment;  risk factor;  systematic review;  vegetarian diet;  vitamin supplementation",
    abstract = "Gallbladder disease (GBD) is one of the most prevalent gastrointestinal disorders in western societies. Etiology is multifactorial and may follow complex interaction between genetic and environmental factors. Dietary intake has been considered as a potentially modifiable risk factor for GBD, because a number of dietary factors have been involved in cholelithiasis pathogenesis. In our aim to evaluate potential usefulness of diet pattern modification for GBD prevention, we perform a systematic review of related epidemiological studies. We define GBD as a disorder in which a patient bears gallstones and/or undergoes surgery for gallstones. We review English-language studies found in the Medline database that occurred from 1973 to 2018. We searched for epidemiological evidence of the role of diet as a potential risk factor for gallstone formation. In particular, we thoroughly inspected intake of fatty acid, cholesterol, carbohydrate, protein, fiber, alcohol, nuts, and coffee and vegetarian eating-pattern effects. Our results show that simple sugar (simple carbohydrate) and saturated fat consumption suggests a positive association with the risk for gallstone formation. Protein, fiber, nuts, coffee, and moderate alcohol intake consistently reduces that probability. Different studies found that fat and cholesterol intake are variable risk factors for GBD; therefore, additional analyses are necessary to clarify their relevance in gallstone formation pathogenesis. GBD is a multifactorial disorder that can be affected both positively and negatively by diet. Although no specific dietary recommendations can be addressed to reduce risk for gallstone formation, healthy diet patterns can be expected to improve prospects for healthy gallbladder function. © 2019 by Begell House, Inc."
}