@article{2990886,
    title = "Effectiveness of an in-office arginine-calcium carbonate paste on dentine hypersensitivity in periodontitis patients: A double-blind, randomized controlled trial",
    author = "Pepelassi, E. and Rahiotis, C. and Peponi, E. and Kakaboura, A. and Vrotsos, I.",
    journal = "Journal of Clinical Periodontology",
    year = "2015",
    volume = "42",
    number = "1",
    pages = "37-45",
    publisher = "Blackwell Munksgaard",
    issn = "0303-6979, 1600-051X",
    doi = "10.1111/jcpe.12319",
    keywords = "arginine;  calcium carbonate;  desensitizing agent;  toothpaste, adolescent;  adult;  aged;  comparative study;  controlled study;  dentin sensitivity;  double blind procedure;  female;  follow up;  human;  male;  middle aged;  periodontics;  periodontitis;  preventive dentistry;  procedures;  randomized controlled trial;  treatment outcome;  visual analog scale;  young adult, Adolescent;  Adult;  Aged;  Arginine;  Calcium Carbonate;  Dental Scaling;  Dentin Desensitizing Agents;  Dentin Sensitivity;  Double-Blind Method;  Female;  Follow-Up Studies;  Humans;  Male;  Middle Aged;  Periodontal Index;  Periodontitis;  Root Planing;  Toothpastes;  Treatment Outcome;  Visual Analog Scale;  Young Adult",
    abstract = "Aim The aim of this single-centre, two-cell, double-blind, randomized controlled clinical study was to evaluate the effectiveness of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing relief on dentine hypersensitivity immediately after scaling and root planing and its sustained relief over a 6-week period. Materials and Methods Fifty periodontitis subjects presenting hypersensitivity were subjected to scaling and root planing and in-office application of either 8% arginine and calcium carbonate desensitizing paste (25 subjects, test group) or fluoride-free prophylaxis paste (25 subjects, control group). Air-blast hypersensitivity was assessed using Schiff and Visual Analogue (VAS) scales at baseline, post-scaling, post-application, 2, 4 and 6 weeks. Results At all evaluation times, the test group presented significant % reduction in hypersensitivity relative to post-scaling (t-test, p < 0.05) (Schiff - Test: 57, 58.6, 60.2, 68; Control: 28.6, 22.2, 23, 23) (VAS - Test: 60, 55.6, 60.1, 68.4; Control: 25.9, 18.2, 20.6, 22.7) and significant % hypersensitivity difference relative to control (ancova, p < 0.05) (Schiff: 38.9, 45.9, 47.4, 57.7; VAS: 49.1, 48.9, 52.6, 61). Conclusion The single in-office application of the 8% arginine-calcium carbonate desensitizing paste after scaling and root planing provided significant immediate reduction in dentine hypersensitivity, which sustained over a 6-week period. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd."
}