@article{2991521, title = "Lateral periodontal cysts arising in periapical sites: A report of two cases", author = "Nikitakis, N.G. and Brooks, J.K. and Melakopoulos, I. and Younis, R.H. and Scheper, M.A. and Pitts, M.A. and Al-Mubarak, H. and Sklavounou, A.", journal = "JOURNAL OF ENDODONTICS", year = "2010", volume = "36", number = "10", pages = "1707-1711", issn = "0099-2399", doi = "10.1016/j.joen.2010.06.015", keywords = "aged; article; case report; differential diagnosis; female; human; male; middle aged; pathology; periodontal disease; radiography; tooth periapical disease, Aged; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Periapical Diseases; Periodontal Cyst", abstract = "Introduction: The lateral periodontal cyst is an uncommon odontogenic developmental lesion and chiefly arises in the alveolar bone between the roots of a pair of erupted teeth or lateral to a tooth root. Two atypical cases of the lateral periodontal cyst occurring in periapical sites are reported. Methods: Both lesions presented as an incidental radiographic finding, appearing as an apical radiolucency with well-circumscribed sclerotic borders. One lesion, initially suspected to be of pulpal origin, persisted after endodontic therapy; the other case was first considered to be an odontogenic keratocyst. A biopsy was performed on each patient for lesional identity. Results: Histopathologic assessment of each lesion was consistent with a lateral periodontal cyst and revealed thin, nonkeratinized epithelial linings containing nodular plaques and clear cells. The cyst walls were thickened and had minimal inflammation. Conclusions: The featured cases show that the lateral periodontal cyst is not always confined to the interradicular region and can masquerade as a lesion of endodontic origin. Aberrant cases warrant long-term surveillance. Copyright © 2010 American Association of Endodontists." }