@article{2992461,
    title = "Blood supply to the oral and maxillofacial tissues following radiation therapy: A prospective ultrasonographic study",
    author = "Semergidis, T. and Vairaktaris, E. and Iatrou, I. and Carageorgis, P. and Martis, C.",
    journal = "JOURNAL OF CRANIO-MAXILLO-FACIAL SURGERY",
    year = "1996",
    volume = "24",
    number = "1",
    pages = "16-23",
    publisher = "Churchill Livingstone",
    issn = "1010-5182",
    doi = "10.1016/S1010-5182(96)80072-2",
    keywords = "adult;  aged;  article;  blood flow;  blood flow velocity;  carotid artery flow;  clinical article;  color ultrasound flowmetry;  common carotid artery;  face;  female;  follow up;  head and neck tumor;  human;  male;  mouth;  mouth tumor;  radiation dose;  radiotherapy;  risk factor;  tissue distribution",
    abstract = "In this prospective clinical study of the early radiation effects on blood supply to the mouth and face, 44 patients (31 men - 13 women, mean age 63.4 yrs) with oral tumors underwent surgery and adjuvant postoperative radiotherapy with conventional fractionation (mean dose at the neck ≃ 50 Gy). Blood flow parameters 1 cm below the bifurcation of the common carotid artery (mean velocity time averaged, lumen diameter, resistivity index-RI) as well as perivascular reaction, were recorded on Color Doppler Imaging video tapes in a series of five consecutive examinations up to six months postirradiation. There were no statistically significant changes shown between the initial and follow-up examinations for any of the parameters investigated. There was no difference in blood flow between the ipsilateral (operated-irradiated) and contralateral side of the neck. Results did not seem to correlate with known vascular disease risk factors such as sex, arterial pressure, cholesterol levels, smoking and diabetes. After the effect of age was controlled, flow measurements remained statistically stable. Radiation dosage did not appear to influence carotid flow parameters. Perivascular reaction had the highest peak immediately postirradiation but regressed with time. This study suggests that therapeutic radiation of the neck at this dose level may not have important effects on the maxillofacial region blood supply for approximately eight months postoperatively; however, these patients should be closely evaluated for symptoms or signs of carotid artery lesions on a long-term basis."
}