@article{2995941,
    title = "The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na+, K+)-, Mg2+- ATPase activities, antioxidant status, and learning performance of aged rats",
    author = "Carageorgiou, H. and Sideris, A.C. and Messari, I. and Liakou, C.I. and Tsakiris, S.",
    journal = "Neuropsychiatric Disease and Treatment",
    year = "2008",
    volume = "4",
    number = "4",
    pages = "687-699",
    publisher = "Dove Medical Press Ltd",
    issn = "1176-6328, 1178-2021",
    doi = "10.2147/ndt.s3272",
    keywords = "acetylcholinesterase;  adenosine triphosphatase (magnesium);  adenosine triphosphatase (potassium sodium);  free radical;  norselegiline;  rivastigmine;  sodium chloride, age distribution;  aged;  animal behavior;  animal experiment;  animal tissue;  antioxidant activity;  article;  biochemistry;  brain function;  chronic drug administration;  cognition;  combination chemotherapy;  controlled study;  drug potentiation;  enzyme activation;  enzyme activity;  enzyme inhibition;  learning;  male;  monotherapy;  nonhuman;  passive avoidance;  rat;  recognition;  statistical significance",
    abstract = "We investigated the effects of rivastigmine (a cholinesterase inhibitor) and selegiline ((-)deprenyl, an irreversible inhibitor of monoamineoxidase-B), alone and in combination, on brain acetylcholinesterase (AChE), (Na+, K+)-, Mg2+-ATPase activities, total antioxidant status (TAS), and learning performance, after long-term drug administration in aged male rats. The possible relationship between the biochemical and behavioral parameters was evaluated. Methods: Aged rats were treated (for 36 days) with rivastigmine (0.3 mg/ kg rat/day ip), selegiline (0.25 mg/kg rat/day im), rivastigmine plus selegiline in the same doses and way of administration as separately. Aged and adult control groups received NaCl 0.9% 0.5 ml ip. Results: TAS was lower in aged than in adult rats, rivastigmine alone does not affect TAS, decreases AChE activity, increases (Na+, K+)-ATPase and Mg2+-ATPase activity of aged rat brain and improves cognitive performance. Selegiline alone decreases free radical production and increases AChE activity and (Na+, K+)-ATPase activity, improving cognitive performance as well. In the combination: rivastigmine seems to cancel selegiline action on TAS and AChE activity, while it has additive effect on (Na+, K+)-ATPase activity. In the case of Mg2+-ATPase selegiline appears to attenuate rivastigmine activity. No statistically significant difference was observed in the cognitive performance. Conclusion: Reduced TAS, AChE activity and learning performance was observed in old rats. Both rivastigmine and selesiline alone improved performance, although they influenced the biochemical parameters in a different way. The combination of the two drugs did not affect learning performance. © 2008 Carageorgiou et al, publisher and licensee Dove Medical Press Ltd."
}