@article{2996952,
    title = "Temporal trends in stroke incidence and case-fatality rates in Arcadia, Greece: A sequential, prospective, population-based study",
    author = "Karantali, E. and Vemmos, K. and Tsampalas, E. and Xynos, K. and Karachalia, P. and Lambrou, D. and Angeloglou, S. and Kazakou, M. and Karagianni, A. and Aravantinou-Fatorou, K. and Karakatsani, E. and Bots, M.L. and Karamatzianni, G. and Bellos, S. and Ntiloudis, R. and Lypiridou, M. and Gamvoula, A. and Georgiopoulos, G. and Ajdini, E. and Gatselis, N. and Makaritsis, K. and Korompoki, E. and Ntaios, G.",
    journal = "International Journal of Stroke",
    year = "2022",
    volume = "17",
    number = "1",
    pages = "37-47",
    publisher = "SAGE Publications Inc.",
    issn = "1747-4930, 1747-4949",
    doi = "10.1177/1747493021995594",
    keywords = "adult;  aged;  Article;  case fatality rate;  cerebrovascular accident;  female;  Greece;  human;  incidence;  major clinical study;  male;  mortality rate;  population research;  prospective study;  risk assessment;  risk factor;  sex difference;  trend study;  cerebrovascular accident;  income;  register, Greece;  Humans;  Incidence;  Income;  Prospective Studies;  Registries;  Stroke",
    abstract = "Background: Stroke incidence and case-fatality are reported to decline in high-income countries during the last decades. Epidemiological studies are important for health services to organize prevention and treatment strategies. Aims: The aim of this population-based study was to determine temporal trends of stroke incidence and case-fatality rates of first-ever stroke in Arcadia, a prefecture in southern Greece. Methods: All first-ever stroke cases in the Arcadia prefecture were ascertained using the same standard criteria and multiple overlapping sources in three study periods: from November 1993 to October 1995; 2004; and 2015–2016. Crude and age-adjusted to European population incidence rates were compared using Poisson regression. Twenty-eight days case fatality rates were estimated and compared using the same method. Results: In total, 1315 patients with first-ever stroke were identified. The age-standardized incidence to the European population was 252 per 100,000 person-years (95% CI 231–239) in 1993/1995, 252 (95% CI 223–286) in 2004, and 211 (192–232) in 2015/2016. The overall age- and sex-adjusted incidence rates fell by 16% (incidence rates ratio 0.84, 95% CI: 0.72–0.97). Similarly, 28-day case-fatality rate decreased by 28% (case fatality rate ratio = 0.72, 95% CI: 0.58–0.90). Conclusions: This population-based study reports a significant decline in stroke incidence and mortality rates in southern Greece between 1993 and 2016. © 2021 World Stroke Organization."
}