@article{2996994, title = "Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease", author = "Oliveira, L.M.A. and Gasser, T. and Edwards, R. and Zweckstetter, M. and Melki, R. and Stefanis, L. and Lashuel, H.A. and Sulzer, D. and Vekrellis, K. and Halliday, G.M. and Tomlinson, J.J. and Schlossmacher, M. and Jensen, P.H. and Schulze-Hentrich, J. and Riess, O. and Hirst, W.D. and El-Agnaf, O. and Mollenhauer, B. and Lansbury, P. and Outeiro, T.F.", journal = "npj Parkinson's Disease", year = "2021", volume = "7", number = "1", publisher = "Institute of Geographic Sciences and Natural Resources Research", issn = "2373-8057", doi = "10.1038/s41531-021-00203-9", abstract = "With the advent of the genetic era in Parkinson’s disease (PD) research in 1997, α-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of $51.9 billion in the US alone. Since the initial association with PD, hundreds of researchers have contributed to elucidating the functions of α-synuclein in normal and pathological states, and these remain critical areas for continued research. With this position paper the authors strive to achieve two goals: first, to succinctly summarize the critical features that define α-synuclein’s varied roles, as they are known today; and second, to identify the most pressing knowledge gaps and delineate a multipronged strategy for future research with the goal of enabling therapies to stop or slow disease progression in PD. © 2021, The Author(s)." }