@article{2997493,
    title = "Paraneoplastic cerebellar degeneration in a patient with breast cancer associated with carbonic anhydrase–related protein VIII autoantibodies",
    author = "Prevezianou, A. and Tzartos, J.S. and Dagklis, I.E. and Bentenidi, E. and Angelopoulos, P. and Bostantjopoulou, S.",
    journal = "Journal of Neuroimmunology",
    year = "2020",
    volume = "344",
    publisher = "Elsevier B.V.",
    issn = "0165-5728",
    doi = "10.1016/j.jneuroim.2020.577242",
    keywords = "autoantibody;  carbonate dehydratase;  carbonic anhydrase related protein VIII;  immunoglobulin;  oligoclonal band;  paclitaxel;  unclassified drug;  autoantibody;  CA8 protein, human;  protein binding;  tumor marker, aged;  antibody titer;  Article;  Babinski reflex;  bradyphrenia;  breast cancer;  cancer adjuvant therapy;  cancer surgery;  case report;  cerebellum disease;  cerebrospinal fluid analysis;  clinical article;  cytoplasm;  diplopia;  dizziness;  drug withdrawal;  dysarthria;  dyskinesia;  dysmetria;  female;  follow up;  gait disorder;  human;  immobility;  leukoencephalopathy;  leukopenia;  multiple cycle treatment;  neurologic examination;  nuclear magnetic resonance imaging;  paraneoplastic neuropathy;  priority journal;  protein cerebrospinal fluid level;  Purkinje cell;  tremor;  animal;  breast tumor;  cerebellum;  complication;  Haplorhini;  HEK293 cell line;  metabolism;  paraneoplastic neuropathy;  pathology;  physiology, Aged;  Animals;  Autoantibodies;  Biomarkers, Tumor;  Breast Neoplasms;  Cerebellum;  Female;  Haplorhini;  HEK293 Cells;  Humans;  Paraneoplastic Cerebellar Degeneration;  Protein Binding",
    abstract = "Paraneoplastic cerebellar degeneration is a neurological syndrome resulting from immune-mediated dysfunction of Purkinje cells and commonly is associated with a tumor. In most cases, well-characterized onconeural antibodies are detected, such as anti-Yo and anti-Ri antibodies. Carbonic anhydrase-related protein VIII (CARP VIII) antibodies associated with paraneoplastic cerebellar degeneration have been previously described in only two cases. Herein, we present a 75-year-old female who developed progressive cerebellar ataxia. Anti-CARP VIII autoantibodies were found at high titres and screening for underlying malignancies revealed a breast cancer. Intravenous immunoglobulin was administered with poor results. Our report further confirms the role of CARP VIII antibodies in cerebellar degeneration. © 2020 Elsevier B.V."
}