@article{2997533,
    title = "Colchicine for stroke prevention in patients with coronary artery disease: a systematic review and meta-analysis",
    author = "Katsanos, A.H. and Palaiodimou, L. and Price, C. and Giannopoulos, S. and Lemmens, R. and Kosmidou, M. and Georgakis, M.K. and Weimar, C. and Kelly, P.J. and Tsivgoulis, G.",
    journal = "European Journal of Paediatric Neurology",
    year = "2020",
    volume = "27",
    number = "6",
    pages = "1035-1038",
    publisher = "Wiley-Blackwell Publishing Ltd",
    issn = "1090-3798",
    doi = "10.1111/ene.14198",
    keywords = "colchicine, Article;  cerebrovascular accident;  coronary artery disease;  follow up;  human;  incidence;  low drug dose;  meta analysis;  priority journal;  randomized controlled trial (topic);  risk reduction;  systematic review;  therapy effect",
    abstract = "Background and purpose: Although clinical trials suggest that colchicine may reduce the risk of vascular events in patients with a history of coronary artery disease, its effect on the prevention of cerebrovascular events still remains unclear. Methods: A systematic review and meta-analysis was performed of all available randomized controlled trials (RCTs) reporting on incident strokes during the follow-up of patients with a history of cardiovascular disease randomized to colchicine treatment or control (placebo or usual care). Results: Four RCTs were identified, including a total of 5553 patients (mean age 61 years, 81% males), with a follow-up ranging from 1 to 36 months. Colchicine treatment was associated with a significantly lower risk of incident stroke during follow-up compared to control (risk ratio 0.31, 95% confidence interval 0.13–0.71), without heterogeneity across included studies (I2 = 0%). Based on the pooled incident stroke rate of control groups (0.9%) in the included RCTs, it was estimated that administration of low-dose colchicine to 161 patients with coronary artery disease would prevent one stroke during a follow-up of 23 months. Conclusion: Colchicine treatment decreases stroke risk in patients with a history of coronary artery disease. The effect of colchicine in secondary stroke prevention is currently being evaluated in an ongoing RCT. © 2020 European Academy of Neurology"
}