@article{2997872,
    title = "Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia",
    author = "Slot, R.E.R. and Sikkes, S.A.M. and Berkhof, J. and Brodaty, H. and Buckley, R. and Cavedo, E. and Dardiotis, E. and Guillo-Benarous, F. and Hampel, H. and Kochan, N.A. and Lista, S. and Luck, T. and Maruff, P. and Molinuevo, J.L. and Kornhuber, J. and Reisberg, B. and Riedel-Heller, S.G. and Risacher, S.L. and Roehr, S. and Sachdev, P.S. and Scarmeas, N. and Scheltens, P. and Shulman, M.B. and Saykin, A.J. and Verfaillie, S.C.J. and Visser, P.J. and Vos, S.J.B. and Wagner, M. and Wolfsgruber, S. and Jessen, F. and Boada, M. and de Deyn, P.P. and Jones, R. and Frisoni, G. and Spiru, L. and Nobili, F. and Freund-Levi, Y. and Soininen, H. and Verhey, F. and Wallin, Å.K. and Touchon, J. and Rikkert, M.O. and Rigaud, A.-S. and Bullock, R. and Tsolaki, M. and Vellas, B. and Wilcock, G. and Froelich, L. and Bakardjian, H. and Benali, H. and Bertin, H. and Bonheur, J. and Boukadida, L. and Boukerrou, N. and Chiesa, P. and Colliot, O. and Dubois, B. and Dubois, M. and Epelbaum, S. and Gagliardi, G. and Genthon, R. and Habert, M.-O. and Houot, M. and Kas, A. and Lamari, F. and Levy, M. and Metzinger, C. and Mochel, F. and Nyasse, F. and Poisson, C. and Potier, M.-C. and Revillon, M. and Santos, A. and Andrade, K.S. and Sole, M. and Surtee, M. and Thiebaud de Schotten, M. and Vergallo, A. and Younsi, N. and van der Flier, W.M. and Alzheimer's Disease Neuroimaging Initiative and DESCRIPA working group and INSIGHT-preAD study group and SCD-I working group",
    journal = "American Journal of Alzheimer's Disease and other Dementias",
    year = "2019",
    volume = "15",
    number = "3",
    pages = "465-476",
    publisher = "ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA",
    issn = "1533-3175",
    doi = "10.1016/j.jalz.2018.10.003",
    keywords = "apolipoprotein E4, adult;  aged;  Alzheimer disease;  Article;  cognition assessment;  cognitive defect;  cohort analysis;  controlled study;  dementia;  disease exacerbation;  female;  frontotemporal dementia;  human;  incidence;  major clinical study;  male;  memory;  Mini Mental State Examination;  priority journal;  risk assessment;  risk factor;  subjective cognitive decline;  very elderly;  clinical trial;  cognitive defect;  dementia;  middle aged;  multicenter study;  psychology;  self concept;  self evaluation, Aged;  Aged, 80 and over;  Cognitive Dysfunction;  Cohort Studies;  Dementia;  Diagnostic Self Evaluation;  Disease Progression;  Female;  Humans;  Incidence;  Male;  Middle Aged;  Risk Factors;  Self Concept",
    abstract = "Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. © 2018 The Authors"
}