@article{2997882,
    title = "The Cretan Aging Cohort: Cohort Description and Burden of Dementia and Mild Cognitive Impairment",
    author = "Zaganas, I.V. and Simos, P. and Basta, M. and Kapetanaki, S. and Panagiotakis, S. and Koutentaki, I. and Fountoulakis, N. and Bertsias, A. and Duijker, G. and Tziraki, C. and Scarmeas, N. and Plaitakis, A. and Boumpas, D. and Lionis, C. and Vgontzas, A.N.",
    journal = "American Journal of Alzheimer's Disease and other Dementias",
    year = "2019",
    volume = "34",
    number = "1",
    pages = "23-33",
    publisher = "SAGE Publications Inc.",
    issn = "1533-3175",
    doi = "10.1177/1533317518802414",
    keywords = "adult;  aged;  aging;  Article;  clinical trial;  cognition;  cohort analysis;  dementia;  disease burden;  female;  follow up;  human;  Independent Activities of Daily Living scale;  major clinical study;  male;  middle aged;  mild cognitive impairment;  Mini Mental State Examination;  phase 1 clinical trial;  phase 2 clinical trial;  prevalence;  questionnaire;  semi structured interview;  very elderly;  cognitive defect;  cost of illness;  dementia;  dementia assessment;  Greece, Aged;  Aged, 80 and over;  Aging;  Cognitive Dysfunction;  Cohort Studies;  Cost of Illness;  Dementia;  Female;  Greece;  Humans;  Male;  Mental Status and Dementia Tests;  Middle Aged;  Prevalence",
    abstract = "Our aim was to explore the burden of dementia in the Cretan Aging Cohort, comprised of 3140 persons aged ≥60 years (56.8% women, 5.8 ± 3.3 years formal education, 86.2% living in rural areas) who attended selected primary health-care facilities on the island of Crete, Greece. In the first study phase, a formal diagnosis of dementia had been reached in 4.0% of the participants. However, when selected 505 participants underwent thorough neuropsychiatric evaluation in the second phase of this study (344 with Mini-Mental State Examination [MMSE] <24 and 161 with MMSE ≥24), and results were extrapolated to the entire cohort, the prevalence of dementia and mild cognitive impairment was estimated at 10.8% (9.7%-11.9%) and 32.4% (30.8%-34.0%), respectively. Using both the field diagnostic data and the extrapolated data, the highest dementia prevalence (27.2%) was found in the 80- to 84-year-old group, who also showed the lowest educational level, apparently due to lack of schooling during World War II. © The Author(s) 2018."
}