@article{2998016,
    title = "Stroke recurrence and mortality in northeastern Greece: the Evros Stroke Registry",
    author = "Tsivgoulis, G. and Katsanos, A.H. and Patousi, A. and Pikilidou, M. and Birbilis, T. and Mantatzis, M. and Yavropoulou, M. and Zompola, C. and Triantafyllou, S. and Papanas, N. and Skendros, P. and Terzoudi, A. and Georgiadis, G.S. and Zebekakis, P. and Maltezos, E. and Piperidou, C. and Heliopoulos, I. and Vadikolias, K.",
    journal = "Egyptian Journal of Neurology, Psychiatry and Neurosurgery",
    year = "2018",
    volume = "265",
    number = "10",
    pages = "2379-2387",
    publisher = "Dr. Dietrich Steinkopff Verlag GmbH and Co. KG",
    doi = "10.1007/s00415-018-9005-6",
    keywords = "adult;  age;  aged;  Article;  brain hemorrhage;  brain ischemia;  cerebrovascular accident;  comparative study;  controlled study;  disease registry;  female;  follow up;  Greece;  health survey;  human;  hypertension;  incidence;  major clinical study;  male;  medical history;  mortality;  mortality rate;  mortality risk;  priority journal;  prospective study;  recurrence risk;  recurrent disease;  risk assessment;  stroke patient;  stroke survivor;  subarachnoid hemorrhage;  cerebrovascular accident;  Greece;  middle aged;  recurrent disease;  very elderly, Adult;  Aged;  Aged, 80 and over;  Brain Ischemia;  Cerebral Hemorrhage;  Female;  Follow-Up Studies;  Greece;  Humans;  Incidence;  Male;  Middle Aged;  Prospective Studies;  Recurrence;  Stroke;  Subarachnoid Hemorrhage",
    abstract = "Up to date there is no population-based study from Greece providing long-term data on incidence of both all-cause mortality and stroke recurrence for patients with first ever stroke (FES). Adult patients with FES were registered during a 24-month period (2010–2012) and followed-up for 12 months. We calculated cumulative incidences of stroke mortality and recurrence. Univariable and multivariable Cox proportional hazards regression analyses were used to identify independent determinants of 1-year mortality and 1-year stroke recurrence. We prospectively documented 703 first ever stroke cases (mean age 75 ± 12 years; 52.8% males; ischemic stroke 80.8%, intracerebral hemorrhage 11.8%, subarachnoid hemorrhage 4.4%, undefined 3.0%) with a total follow-up time of 119,805 person-years. The cumulative incidence rates of mortality of all FES patients at 28 days, 3 months and 1 year were 21.3% (95% CI 18.5–24.5%), 26% (95% CI 22.9–29.4%) and 34.7% (95% CI 31.3–38.3%), respectively. The risk of 1-year mortality was independently (p < 0.05) associated with advancing age, history of hypertension, increased stroke severity on admission, and hemorrhagic FES type. Cumulative 1-year stroke mortality differed according to both index FES type (ischemic vs. hemorrhage; p < 0.001), but also across different ischemic stroke subtypes (p = 0.025). The cumulative incidence rates of recurrent stroke at 28 days, 3 months and 1 year were 2.0% (95% CI 1.2–3.6%), 4.2% (2.8–6.2%) and 6.7% (5.1–8.8%), respectively. Comparable to other population-based surveys, our study reports 1-year mortality and stroke recurrence rates in patients with FES. These findings highlight the need for effective secondary prevention strategies in a border region of southeastern Europe, which exhibits very high FES incidence rates. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature."
}