@article{2998193,
    title = "OCT-Angiography for monitoring and managing neovascular age-related macular degeneration",
    author = "Malamos, P. and Tsolkas, G. and Kanakis, M. and Mylonas, G. and Karatzenis, D. and Oikonomopoulos, N. and Lakoumentas, J. and Georgalas, I.",
    journal = "Current Eye Research",
    year = "2017",
    volume = "42",
    number = "12",
    pages = "1689-1697",
    publisher = "Taylor and Francis Ltd.",
    issn = "0271-3683, 1460-2202",
    doi = "10.1080/02713683.2017.1356336",
    keywords = "adult;  Article;  B scan;  fluorescence angiography;  follow up;  human;  indocyanine green angiography;  intermethod comparison;  major clinical study;  observational study;  optical coherence tomography;  optical coherence tomography angiography;  priority journal;  subretinal neovascularization;  wet macular degeneration;  aged;  antagonists and inhibitors;  female;  fluorescence angiography;  male;  middle aged;  multimodal imaging;  optical coherence tomography;  physiology;  prospective study;  sensitivity and specificity;  subretinal neovascularization;  visual acuity;  wet macular degeneration, angiogenesis inhibitor;  coloring agent;  indocyanine green;  vasculotropin A;  VEGFA protein, human, Aged;  Angiogenesis Inhibitors;  Choroidal Neovascularization;  Coloring Agents;  Female;  Fluorescein Angiography;  Humans;  Indocyanine Green;  Male;  Middle Aged;  Multimodal Imaging;  Prospective Studies;  Sensitivity and Specificity;  Tomography, Optical Coherence;  Vascular Endothelial Growth Factor A;  Visual Acuity;  Wet Macular Degeneration",
    abstract = "Purpose: To evaluate the combined use of optical coherence tomography and angiography (OCT-A) for imaging choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration (nAMD). Materials and Methods: This prospective observational study was conducted from May 2015 to April 2017. Included in the study were 54 patients (n = 63 eyes), all of whom had CNV secondary to nAMD and all of whom had been examined by OCT-A. Angioscans (3x3 and 6 × 6) and conventional B-scan OCT scans were obtained for all patients at baseline and at various times during the 24-month follow-up period. For diagnostic confirmation, conventional imaging methods fluorescein angiography (FA) and indocyanine green angiography (ICGA) were performed at baseline. A total of 13 patients (n = 15 eyes) underwent serial imaging during 34 follow-up visits. The main outcomes included (i) determination of OCT-A sensitivity for the detection of CNV (classic and occult) and (ii) the correlation between B-scan OCT and OCT-A vis-à-vis consecutive follow-up changes. Results: At baseline, the detection rate (i.e., overall sensitivity) of OCT-A for detecting CNV was 64.4% (75.7 and 48.0% for classic and occult CNV, respectively), independent of prior treatment status. In terms of quality, 6 × 6 angioscans were superior to 3 × 3. Moreover, specific CNV morphologic patterns by B-scan OCT did not correlate with lesion composition. Correspondence between OCT-A and B-scan OCT was observed in only 53% of the cases. Conclusions: OCT-A may prove to be a valuable adjunctive diagnostic tool for the interpretation of CNV, as it not only reduces the need for invasive angiographic procedures but also facilitates the follow-up process. © 2017 Taylor & Francis Group, LLC."
}