@article{2998304,
    title = "Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria",
    author = "Höglinger, G.U. and Respondek, G. and Stamelou, M. and Kurz, C. and Josephs, K.A. and Lang, A.E. and Mollenhauer, B. and Müller, U. and Nilsson, C. and Whitwell, J.L. and Arzberger, T. and Englund, E. and Gelpi, E. and Giese, A. and Irwin, D.J. and Meissner, W.G. and Pantelyat, A. and Rajput, A. and van Swieten, J.C. and Troakes, C. and Antonini, A. and Bhatia, K.P. and Bordelon, Y. and Compta, Y. and Corvol, J.-C. and Colosimo, C. and Dickson, D.W. and Dodel, R. and Ferguson, L. and Grossman, M. and Kassubek, J. and Krismer, F. and Levin, J. and Lorenzl, S. and Morris, H.R. and Nestor, P. and Oertel, W.H. and Poewe, W. and Rabinovici, G. and Rowe, J.B. and Schellenberg, G.D. and Seppi, K. and van Eimeren, T. and Wenning, G.K. and Boxer, A.L. and Golbe, L.I. and Litvan, I. and Wenning, G.K. and Höglinger, G.U. and Morris, H.R. and Litvan, I. and Kassubek, J. and Corvol, J.-C. and Whitwell, J.L. and Levin, J. and van Swieten, J. and Bhatia, K.P. and Josephs, K.A. and Seppi, K. and Golbe, L.I. and Grossman, M. and Dodel, R. and Lorenzl, S. and van Eimeren, T. and Arzberger, T. and Müller, U. and Poewe, W. and Oertel, W.H. and Compta, Y. and Bordelon, Y. and the Movement Disorder Society-endorsed PSP Study Group",
    journal = "Movement Disorders",
    year = "2017",
    volume = "32",
    number = "6",
    pages = "853-864",
    publisher = "John Wiley and Sons Inc",
    issn = "0885-3185, 1531-8257",
    doi = "10.1002/mds.26987",
    keywords = "akinesia;  Article;  body position;  clinical feature;  cognitive defect;  consensus development;  diagnostic imaging;  evidence based medicine;  eye movement disorder;  genetic analysis;  human;  laboratory test;  motor dysfunction;  priority journal;  progressive supranuclear palsy;  medical society;  pathophysiology;  practice guideline;  progressive supranuclear palsy;  standards, Humans;  Practice Guidelines as Topic;  Societies, Medical;  Supranuclear Palsy, Progressive",
    abstract = "Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence- and consensus-based revision of the clinical diagnostic criteria for PSP. Methods: We searched the PubMed, Cochrane, Medline, and PSYCInfo databases for articles published in English since 1996, using postmortem diagnosis or highly specific clinical criteria as the diagnostic standard. Second, we generated retrospective standardized clinical data from patients with autopsy-confirmed PSP and control diseases. On this basis, diagnostic criteria were drafted, optimized in two modified Delphi evaluations, submitted to structured discussions with consensus procedures during a 2-day meeting, and refined in three further Delphi rounds. Results: Defined clinical, imaging, laboratory, and genetic findings serve as mandatory basic features, mandatory exclusion criteria, or context-dependent exclusion criteria. We identified four functional domains (ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction) as clinical predictors of PSP. Within each of these domains, we propose three clinical features that contribute different levels of diagnostic certainty. Specific combinations of these features define the diagnostic criteria, stratified by three degrees of diagnostic certainty (probable PSP, possible PSP, and suggestive of PSP). Clinical clues and imaging findings represent supportive features. Conclusions: Here, we present new criteria aimed to optimize early, sensitive, and specific clinical diagnosis of PSP on the basis of currently available evidence. © 2017 International Parkinson and Movement Disorder Society. © 2017 International Parkinson and Movement Disorder Society"
}