@article{2998798,
    title = "Determinants of secondary hyperparathyroidism in bariatric patients after roux-en-y gastric bypass or sleeve gastrectomy: A pilot study",
    author = "Alexandrou, A. and Tsoka, E. and Armeni, E. and Rizos, D. and Diamantis, T. and Augoulea, A. and Panoulis, C. and Liakakos, T. and Lambrinoudaki, I.",
    journal = "International Journal of Endocrinology",
    year = "2015",
    volume = "2015",
    publisher = "Hindawi Publishing Corporation",
    issn = "1687-8337, 1687-8345",
    doi = "10.1155/2015/984935",
    keywords = "25 hydroxyvitamin D;  calcium;  magnesium, adult;  age;  Article;  controlled study;  female;  human;  major clinical study;  male;  morbid obesity;  pilot study;  postmenopause;  premenopause;  prevalence;  priority journal;  risk assessment;  risk factor;  Roux en Y gastric bypass;  secondary hyperparathyroidism;  sex difference;  sleeve gastrectomy;  smoking;  stomach bypass;  weight reduction",
    abstract = "Objective. Nutritional deficiencies are common after bariatric surgery. We aimed to assess the prevalence and possible predictors of secondary hyperparathyroidism (SHPT) in bariatric patients. Methods. A total of 95 patients who had undergone Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were assessed after a median of 3 years after surgery. Anthropometric/demographic and weight-loss parameters were compared according to the presence of SHPT, independently for men/premenopausal women and postmenopausal women. Results. SHPT was highly prevalent (men/premenopausal women, 52.1%; postmenopausal women, 31.9%). Among men/premenopausal women, multivariate analysis indicated that SHPT was predicted by (a) 25-hydroxyvitamin D levels (Exp(B) = 0.869, P-value = 0.037), independently of age, sex, smoking; (b) calcium (Exp(B) = 0.159, P-value = 0.033) and smoking, independently of age and sex; (c) magnesium (Exp(B) = 0.026, P-value = 0.046) and smoking, independently of age and sex. Among postmenopausal women, SHPT was predicted by menopausal age independently of age, smoking, and levels of 25-hydroxyvitamin D or calcium. The development of SHPT was not associated with the type of surgery. Conclusions. RYGB and SG exhibited similar effects regarding the regulation of the hypothalamus-pituitary-parathyroid axis after surgery. Vitamin D status and menopausal age appear to determine SHPT on the long term. SHPT should be sought and vigorously treated with calcium and vitamin D supplementation. © 2015 Andreas Alexandrou et al."
}