@article{2999206,
    title = "Restoration of the photoreceptor layer and improvement of visual acuity in successfully treated optic disc pit maculopathy: A long follow-up study by optical coherence tomography",
    author = "Theodossiadis, G.P. and Grigoropoulos, V.G. and Liarakos, V.S. and Rouvas, A. and Emfietzoglou, I. and Theodossiadis, P.G.",
    journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",
    year = "2012",
    volume = "250",
    number = "7",
    pages = "971-979",
    issn = "0721-832X, 1435-702X",
    doi = "10.1007/s00417-011-1918-z",
    keywords = "absorption;  article;  central foveal thickness;  disease association;  disease duration;  eye examination;  follow up;  human;  optic disc pit maculopathy;  optic disk;  optical coherence tomography;  photoreceptor;  photoreceptor inner segment;  photoreceptor outer segment;  postoperative period;  priority journal;  retina fovea;  retina maculopathy;  retrospective study;  spectral domain optical coherence tomography;  subretinal fluid;  time domain optical coherence tomography;  treatment outcome;  visual acuity;  visual system parameters, Adolescent;  Adult;  Endotamponade;  Eye Abnormalities;  Female;  Fluorocarbons;  Follow-Up Studies;  Humans;  Laser Coagulation;  Male;  Optic Disk;  Retinal Perforations;  Retinal Photoreceptor Cell Inner Segment;  Retinal Photoreceptor Cell Outer Segment;  Retrospective Studies;  Scleral Buckling;  Tomography, Optical Coherence;  Visual Acuity;  Vitrectomy;  Young Adult",
    abstract = "Purpose: To investigate by optical coherence tomography (OCT) the evolution of the photoreceptor layer and its association with best-corrected visual acuity (BCVA) in optic disc pit (ODP) maculopathy after successful surgical treatment. Methods: Fourteen eyes of 14 patients were included in this study, and followed up from 36 to 95 months (mean 57.36 ± 18.32 months). The follow-up period started at the time of complete subretinal fluid absorption. Examination was performed by time-domain OCT before and after treatment. Spectral-domain OCT was used after treatment. Parameters assessed were type of elevation, central foveal thickness, time elapsed from onset to treatment, type of treatment, BCVA, and inner segment outer segment (IS/OS) junction line. The IS/OS junction was characterized after treatment as intact, interrupted, or absent (not distinguishable). Results: Significant restoration of the IS/OS junction line was first noticed between 6 and 12 months after fluid absorption (p00.02; Wilcoxon signed rank test). Restoration was continuous up to the 24th month of postoperative examination after fluid absorption (p00.14; Wilcoxon signed rank test). BCVA was 0.99 ± 0.38 logMar before treatment, 0.81 ± 0.26 logMar (p00.011; paired t-test) immediately after fluid absorption and 0.61 ± 0.33 logMar (p00.026; one-way ANOVA) 24 months after fluid resolution. BCVA was significantly positively correlated with the integrity of the IS/OS junction line during follow-up (Pearson r00.775; p<0.001). Conclusions: The IS/OS junction restoration cannot be detected immediately after fluid resolution in the majority of cases. It became evident 6-12 months later and was completed 24 months after fluid absorption. Improvement in BCVA was noticed only during the first 2 years of follow-up. No significant changes were noticed in BCVA or the IS/OS line after 2 years. Among the studied variables, the final photoreceptor layer condition and BCVA immediately after fluid absorption are the main factors predicting final BCVA after successful surgical treatment of ODP maculopathy. © Springer-Verlag 2012."
}