@article{3000178,
    title = "Ancestral cancer genes shaping evo-devo: An integrated biochemical and computational approach (Review)",
    author = "Vlachakis, D. and Papakonstantinou, E. and Efthimiadou, A. and Bacopoulou, F. and Goulielmos, G. and Chrousos, G.P. and Eliopoulos, E.",
    journal = "World Academy of Sciences Journal",
    year = "2020",
    volume = "2",
    number = "4",
    publisher = "Spandidos Publications",
    doi = "10.3892/wasj.2020.48",
    abstract = "Evo-devo has been shaped by a myriad of natural forces, such as environmental factors, opportunism, survival of the fittest and even disease, including cancer. The influ- ence of the environment and evolutionary stress through natural selection has been driving life since the very begin- ning. However, it is not only through the development of jaws and claws that species survive and evolve. Disease is just another tool in nature's arsenal of evolution. A repertoire of gene-coding and non-coding regions, as researchers recently begin to understand, play a pivotal role in diseases, including cancer. The present review focuses on elucidating the role of signaling, metabolism and transcription processes as stake holders of evolutionary and developmental biology, namely evo-devo, under the prism of reduced survival and disease through cancer genes. The mechanisms through which ances- tral cancer genes can shape evolution and development, when ‘cancer’ is viewed as a robust, evolvable system, are discussed, focusing on its evolutionary origins as an alternative approach. © 2020 Spandidos Publications. All rights reserved."
}