@article{3000572,
    title = "Emergence of staphylococcal scalded skin syndrome associated with a new toxinogenic, methicillin-susceptible staphylococcus aureus clone",
    author = "Doudoulakakis, A. and Spiliopoulou, I. and Syridou, G. and Giormezis, N. and Militsopoulou, M. and Lebessi, E. and Tsolia, M.",
    journal = "Journal of Medical Microbiology",
    year = "2019",
    volume = "68",
    number = "1",
    pages = "48-51",
    publisher = "Microbiology Society",
    issn = "0022-2615, 1473-5644",
    doi = "10.1099/jmm.0.000871",
    keywords = "aerobic respiration control protein A;  amoxicillin plus clavulanic acid;  bacterial protein;  clindamycin;  cotrimoxazole;  epidermolysin;  ermc protein;  fnba protein;  fusb protein;  fusidic acid;  lukf protein;  luks protein;  meticillin;  mupa protein;  oxacillin;  penicillin derivative;  pseudomonic acid;  unclassified drug;  antiinfective agent;  fusidic acid;  meticillin;  pseudomonic acid, antibiotic resistance;  antibiotic therapy;  Article;  bacterial colonization;  bacterial strain;  bacterial virulence;  bacterium isolation;  child;  clinical article;  female;  genotype;  human;  impetigo;  male;  methicillin susceptible Staphylococcus aureus;  nonhuman;  preschool child;  priority journal;  school child;  staphylococcal scalded skin syndrome;  drug effect;  infant;  isolation and purification;  microbiology;  multidrug resistance;  newborn;  staphylococcal scalded skin syndrome;  Staphylococcus aureus, Anti-Bacterial Agents;  Child;  Child, Preschool;  Drug Resistance, Multiple, Bacterial;  Female;  Fusidic Acid;  Humans;  Infant;  Infant, Newborn;  Male;  Methicillin;  Mupirocin;  Staphylococcal Scalded Skin Syndrome;  Staphylococcus aureus",
    abstract = "A sharp increase in staphylococcal scalded skin syndrome (SSSS) cases has been recorded in our settings since 2015, with 31 cases having been documented during the period 2014–2017. The molecular investigation of strains from the above period showed the emergence of a methicillin-susceptible, mupirocin-and fusidic acid-resistant Staphyloccocus aureus clone that belongs to the ST121 complex and carries both epidermolysin (eta/etb) genes. We concluded that the SSSS caused by the newly emerged, highly virulent community-associated-methicillin sensitive S. aureus strains that have been encountered lately is more severe than impetigo. Physicians should be aware of the probability of SSSS epidemics from strains that are resistant to mupirocin and fusidic acid, which have been used irrationally and excessively. © 2019 The Authors."
}