@article{3001129,
    title = "Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping",
    author = "Cyr, D.D. and Allen, A.S. and Du, G.-J. and Ruffin, F. and Adams, C. and Thaden, J.T. and Maskarinec, S.A. and Souli, M. and Guo, S. and Dykxhoorn, D.M. and Scott, W.K. and Fowler, V.G., Jr.",
    journal = "Genes and Immunity",
    year = "2017",
    volume = "18",
    number = "2",
    pages = "95-99",
    publisher = "Nature Publishing Group",
    issn = "1466-4879, 1476-5470",
    doi = "10.1038/gene.2017.6",
    keywords = "admixture mapping;  adult;  African American;  Article;  case control study;  chromosome 6;  comparative study;  controlled study;  disease association;  female;  gene frequency;  gene mapping;  genetic analysis;  genetic susceptibility;  genetic variability;  genetic variation;  genome-wide association study;  HLA system;  human;  immune response;  incidence;  major clinical study;  male;  nonhuman;  priority journal;  prospective study;  single nucleotide polymorphism;  staphylococcal bacteremia;  Staphylococcus aureus;  bacteremia;  genetic predisposition;  genetics;  Staphylococcal Infections, African Americans;  Bacteremia;  Genetic Predisposition to Disease;  Humans;  Incidence;  Polymorphism, Single Nucleotide;  Staphylococcal Infections;  Staphylococcus aureus",
    abstract = "The incidence of Staphylococcus aureus bacteremia (SAB) is significantly higher in African American (AA) than in European-descended populations. We used admixture mapping (AM) to test the hypothesis that genomic variations with different frequencies in European and African ancestral genomes influence susceptibility to SAB in AAs. A total of 565 adult AAs (390 cases with SAB; 175 age-matched controls) were genotyped for AM analysis. A case-only admixture score and a mixed χ 2 (1df) score (MIX) to jointly evaluate both single-nucleotide polymorphism (SNP) and admixture association (P<5.00e-08) were computed using MIXSCORE. In addition, a permutation scheme was implemented to derive multiplicity adjusted P-values (genome-wide 0.05 significance threshold: P<9.46e-05). After empirical multiplicity adjustment, one region on chromosome 6 (52 SNPs, P=4.56e-05) in the HLA class II region was found to exhibit a genome-wide statistically significant increase in European ancestry. This region encodes genes involved in HLA-mediated immune response and these results provide additional evidence for genetic variation influencing HLA-mediated immunity, modulating susceptibility to SAB. © 2017 Macmillan Publishers Limited. All rights reserved."
}