@article{3001459,
    title = "EAACI Molecular Allergology User's Guide",
    author = "Matricardi, P.M. and Kleine-Tebbe, J. and Hoffmann, H.J. and Valenta, R. and Hilger, C. and Hofmaier, S. and Aalberse, R.C. and Agache, I. and Asero, R. and Ballmer-Weber, B. and Barber, D. and Beyer, K. and Biedermann, T. and Bilò, M.B. and Blank, S. and Bohle, B. and Bosshard, P.P. and Breiteneder, H. and Brough, H.A. and Caraballo, L. and Caubet, J.C. and Crameri, R. and Davies, J.M. and Douladiris, N. and Ebisawa, M. and EIgenmann, P.A. and Fernandez-Rivas, M. and Ferreira, F. and Gadermaier, G. and Glatz, M. and Hamilton, R.G. and Hawranek, T. and Hellings, P. and Hoffmann-Sommergruber, K. and Jakob, T. and Jappe, U. and Jutel, M. and Kamath, S.D. and Knol, E.F. and Korosec, P. and Kuehn, A. and Lack, G. and Lopata, A.L. and Mäkelä, M. and Morisset, M. and Niederberger, V. and Nowak-Węgrzyn, A.H. and Papadopoulos, N.G. and Pastorello, E.A. and Pauli, G. and Platts-Mills, T. and Posa, D. and Poulsen, L.K. and Raulf, M. and Sastre, J. and Scala, E. and Schmid, J.M. and Schmid-Grendelmeier, P. and van Hage, M. and van Ree, R. and Vieths, S. and Weber, R. and Wickman, M. and Muraro, A. and Ollert, M.",
    journal = "Pediatric Allergy and Immunology",
    year = "2016",
    volume = "27",
    pages = "1-250",
    publisher = "Wiley-Blackwell Publishing Ltd",
    issn = "0905-6157, 1399-3038",
    doi = "10.1111/pai.12563",
    keywords = "allergen;  Hymenoptera venom;  immunoglobulin E;  lipid transfer protein;  lipocalin;  parvalbumin;  polcalcin;  profilin;  serum albumin;  tropomyosin;  unclassified drug, algorithm;  Article;  asthma;  clinical practice;  cross reaction;  food allergy;  human;  immune response;  immunology;  insect sting;  medical society;  nonhuman;  priority journal;  provocation test;  rhinoconjunctivitis;  skin test",
    abstract = "The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled ‘component-resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd"
}