@article{3003113,
    title = "Polymorphisms of Cx3CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients",
    author = "Passam, A.M. and Sourvinos, G. and Krambovitis, E. and Miyakis, S. and Stavrianeas, N. and Zagoreos, I. and Spandidos, D.A.",
    journal = "AIDS Research and Human Retroviruses",
    year = "2007",
    volume = "23",
    number = "8",
    pages = "1026-1032",
    issn = "0889-2229, 1931-8405",
    doi = "10.1089/aid.2006.0248",
    keywords = "antiretrovirus agent;  chemokine receptor CX3CR1;  chemokine receptor CXCR6;  proteinase inhibitor;  RNA directed DNA polymerase inhibitor;  unclassified drug, adult;  aged;  article;  CD4 lymphocyte count;  controlled study;  female;  haplotype;  highly active antiretroviral therapy;  human;  Human immunodeficiency virus 1;  Human immunodeficiency virus infection;  immune response;  major clinical study;  male;  priority journal;  protein polymorphism;  treatment response;  virus load, Adult;  Aged;  Alleles;  Antiretroviral Therapy, Highly Active;  CD4 Lymphocyte Count;  Female;  HIV Infections;  HIV-1;  Humans;  Kaplan-Meiers Estimate;  Male;  Middle Aged;  Polymorphism, Genetic;  Receptors, Chemokine;  Receptors, Virus;  Viral Load",
    abstract = "The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX 3CR1-V249I, and CX3CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following end-point criteria: (1) time from HAART initiation to undetectable viral load (VL < 50 copies/ml), (2) maximum duration of viral suppression, (3) time from HAART administration until CD4 elevation above 200 cells/μl for patients with baseline CD4 below 200 cells/μl and above 500 cells/μl for patients with baseline CD4 between 200 and 500 cells/μl, respectively, and (4) time from HAART initiation until CD4 reduction below baseline values. Our results revealed an improved immunologic response to HAART in patients with the CX3CR1-249I or CX 3CR1-280M allele. On the contrary, patients with initial VL suppression due to HAART showed a faster virologic failure in the presence of the CXCR6-3K allele. The In1.1T/C polymorphism and H7 haplotype did not reveal any specific effect on HAART response. © Mary Ann Liebert, Inc."
}