@article{3004758,
    title = "Limited Long-Term Naive CD4+ T Cell Reconstitution in Patients Experiencing Viral Load Rebounds during HAART",
    author = "Choremi-Papadopoulou, H. and Tsalimalma, K. and Dafni, U. and Dimitracopoulou, A. and Kordossis, T.",
    journal = "Journal of Medical Virology",
    year = "2004",
    volume = "73",
    number = "2",
    pages = "235-243",
    issn = "0146-6615, 1096-9071",
    doi = "10.1002/jmv.20081",
    keywords = "antiretrovirus agent;  CD28 antigen;  CD38 antigen;  CD4 antigen;  CD45 antigen;  CD8 antigen;  indinavir;  lamivudine;  proteinase inhibitor;  ritonavir;  RNA directed DNA polymerase inhibitor;  virus RNA;  zidovudine, adult;  antigen presenting cell;  antigen recognition;  article;  clinical article;  female;  flow cytometry;  highly active antiretroviral therapy;  human;  Human immunodeficiency virus 1;  Human immunodeficiency virus infection;  immune response;  long term exposure;  lymphocyte count;  male;  memory cell;  statistical significance, Acquired Immunodeficiency Syndrome;  ADP-ribosyl Cyclase;  Adult;  Antigens, CD;  Antigens, CD28;  Antigens, CD38;  Antigens, CD4;  Antigens, CD45;  Antigens, CD8;  Antiretroviral Therapy, Highly Active;  CD4 Lymphocyte Count;  CD8-Positive T-Lymphocytes;  Female;  Flow Cytometry;  HIV Infections;  HIV-1;  Humans;  Immunologic Memory;  Immunophenotyping;  Male;  Membrane Glycoproteins;  Middle Aged;  RNA, Viral;  T-Lymphocyte Subsets;  Viral Load;  Viremia, Human immunodeficiency virus 1",
    abstract = "Long-term (3.5 years) immune reconstitution in relation to viral load response was determined. Plasma HIV-1 RNA was suppressed in 40 patients (full responders) up to 42 months, and 17 patients achieved partial response. The measurements of CD4+ and CD8+ T lymphocyte subsets (CD45RA, CD45RACD62L, CD45RO, CD28, CD38) were carried out by flow cytometry. Full responders had a significant increase of CD4+ and all CD4 + T subsets both up to 6 and from 6 to 42 months, while the increase for partial responders was only up to 6 months. By 6 months, higher slopes were observed in full versus partial responders in the % of CD28 on CD4+ and the % of CD4+ memory subset and in both naïve and memory CD4+ subsets from 6 to 42 months. The percentage of CD8+ and its subsets was decreased significantly in full responders both up to 6 and from 6 to 42 months (except for an increase in the CD8+CD45RA + CD62L+ cells), while in partial responders this decrease was only up to 6 months. Lower slopes were observed in full versus partial responders from 6 to 42 months in the percentages of CD8+, CD8+CD45RO+, CD8+CD28-, and CD8 +CD38+ T cells. In conclusion, full responders have a stronger long-term naive CD4+ T cell subset reconstitution than partial responders. © 2004 Wiley-Liss, Inc."
}