@article{3004786,
    title = "Marrow versus peripheral blood for geno-identical allogeneic stem cell transplantation in acute myelocytic leukemia: Influence of dose and stem cell source shows better outcome with rich marrow",
    author = "Gorin, N.C. and Labopin, M. and Rocha, V. and Arcese, W. and Beksac, M. and Gluckman, E. and Ringden, O. and Ruutu, T. and Reiffers, J. and Bandini, G. and Falda, M. and Zikos, P. and Willemze, R. and Frassoni, F. and Abecasis, M. and Abráhamová, J. and Afanassiev, B.V. and Aglietta, M. and Alabdulaaly, A. and Aleinikova, O. and Paolo Alessandrino, E. and Al Shemmari, S.H. and Amadori, D. and Amadori, S. and Amos, T. and Andolina, M. and Andreesen, R. and Angelucci, E. and Anhuf, J. and Arnold, R. and Arpaci, F. and Attal, M. and Azevedo, W. and Azim, H.A. and Baccarani, M. and Bacigalupo, A. and Barbui, T. and Bargetzi, M. and Barnard, D.L. and Bartsch, H.H. and Baruchel, A. and Battista, C. and Bay, J.-O. and Bayik, M. and Bazarbachi, A. and Beguin, Y. and López, J.L.B. and Benedek, I. and Benedetti, F. and Bengala, C. and Berrebi, A. and Besalduch, J. and Biesma, D. and Biron, P. and Björkholm, M. and Blaise, D. and Blesing, N.E. and Boasson, M. and Bobev, D. and Boccadoro, M. and Bolaman, Z. and Boogaerts, M.A. and Bordessoule, D. and Bosi, A. and Aida, B.S. and Bourhis, J.H. and Bourikas, G. and Bowen, D.T. and Bregni, M. and Bries, G. and Brinch, L. and Brittain, D. and Bron, D. and Brune, M. and Bullorsky, E.O. and Bunjes, D. and Burdach, S. and Burnett, A.K. and Buzyn, A. and Caballero, D. and Cagirgan, S. and Cahn, J.-Y. and Canepa, C.O. and Cao, A. and Carella, A.M. and Carrera, F.D. and Carret, A.-S. and Cascinu, S. and Castel, V. and Caswell, M. and Cavanna, L. and Cetto, G.L. and Chapuis, B. and Chasty, R. and Chen, Y.-C. and Chisesi, T. and Chopra, R. and Chybicka, A. and Clark, R.E. and Colombat, P. and Colovic, M.D. and Constenla-Figueiras, M. and Contreras, M. and Contu, L. and Cordonnier, C. and Cornelissen, J.J. and Cornish, J. and Coser, P. and Costa, N. and Coze, C. and Craddock, C. and Crown, J. and Culligan, D.J. and Danova, M. and Darbyshire, P.J. and Davies, J.M. and de Bock, R. and de Pablos Gallego, J.M. and De Prijck, B. and de Revel, T. and De Rossi, G. and De Souza, C.A. and Deb, G. and Degos, L. and Demuynck, H. and Dervenoulas, I. and Di Bartolomeo, P. and Di Renzo, N. and Diaz, M.A. and Diehl, V. and Diez-Martin, J.L. and Dincer, S. and Giorgio, D. and Dmoszynska, A. and Doelken, G. and Peter, P.D. and Dulley, F. and Easow, J. and Ebell, W. and Efremidis, A. and Ehninger, G. and Eichler, H. and Eimermacher, H. and Enno, A. and Errazquin, L. and Aguado, J.E. and Everaus, H. and Fagioli, F. and Fanin, R. and Fassas, A. and Fasth, A. and Faulkner, L.B. and Fauser, A.A. and Feldman, L. and Feremans, W. and Ferhanoglu, B. and Fernández, M.N. and Fernández-Ranada, J.M. and Ferrant, A. and Ferrara, F. and Finke, J. and Fischer, A. and Fischer, J. and Fitzsimons, T. and Floristan, F. and Forjaz de Lacerda, J.M.F. and Fossati-Bellani, F. and Fosser, V. and Franklin, I. and Freund, M. and Frickhofen, N. and Gabbas, A. and Gadner, H. and Gallamini, A. and Galvin, M.C. and López, J.G. and García-Conde, J. and Gaska, T. and Gastl, G. and Gedikoglu, G. and Ghavamzadeh, A. and Gianni, A. and Gibson, B.E. and Gil, J.L. and Gilleece, M.H. and Gisselbrecht, C. and Glass, B. and Gmür, J. and Göbel, U. and Goldman, J.M. and Goldstone, A.H. and San Miguel, J.D.G. and González-López, M.-A. and Grafakos, S. and Gramatzki, M. and Grañena, A. and Gratecos, N. and Gratwohl, A. and Greinix, H.T. and Gugliotta, L. and Guilhot, F. and Guimaraes, J.E. and Gülbas, Z. and Gulyuz, O. and Gurman, G. and Gutierrez, M.M. and Haas, R. and Hamladji, R.-M. and Hamon, M.D. and Hansen, N.E. and Harhalakis, N. and Harousseau, J.L. and Hartenstein, R. and Hartmann, C.O. and Hausmaninger, H. and Haznedar, R. and Heit, W. and Hellmann, A. and Herrmann, R.P. and Hertenstein, B. and Hess, U. and Hinterberger, W. and Ho, A.D. and Hoelzer, D. and Holowiecki, J. and Horst, H.-A. and Hossfeld, D.K. and Huebsch, L. and Hunter, A.E. and Iacopino, P. and Iannitto, E. and Indrák, K. and Iriondo, A. and Izzi, T. and Jackson, G.L. and Jacobs, P. and Jacobsen, N. and Janvier, M. and Jebavy, L. and Joensuu, H. and Joerg, S. and Jones, F.G.C. and Jouet, J.P. and Joyner, M.V. and Juliusson, G. and Jürgens, H. and Kalayoglu-Besisik, S. and Kalman, N. and Kalmanti, M. and Kansoy, S. and Kansu, E. and Kanz, L. and Karianakis, G. and Kernéis, Y. and Khalifeh, O. and Khomenko, V. and Kienast, J. and Killick, S. and Kirchner, H.H. and Klingebiel, T. and Knauf, W. and Koenigsmann, M. and Koistinen, P. and Koivunen, E. and Kolb, H.-J. and Kolbe, K. and Koller, E. and Komarnicki, M. and Koscielniak, E. and Kovacsovics, T. and Kowalczyk, J.R. and Koza, V. and Kozak, T. and Kugler, J. and Kuliczkowski, K. and Kvaloy, S. and Labar, B. and Laciura, P. and Palacios, J.J.L. and Lakota, J. and Lambertenghi, D.G. and Lange, A. and Lanza, F. and Isasti, R.L. and Lauria, F. and Le Moine, F. and Leblond, V. and Lelli, G. and Lenhoff, S. and Leon, L.A. and Leoncini-Franscini, L. and Leone, G. and Leoni, P. and Levis, A. and Leyvraz, S. and Liberati, M. and Link, H. and Linkesch, W. and Liso, V. and Lisukov, I.A. and Littlewood, T. and Ljungman, P. and Locatelli, F. and Losonczy, H. and Lotz, J.-P. and Ludwig, H. and Lukac, J. and Lutz, D. and Macchia, P. and Madrigal, A. and Maiolino, A. and Majolino, I. and Eloy-García, J.M. and Malesevic, M. and Mandelli, F. and Marc, A. and Marcus, R. and Marianska, B. and Markuljak, I. and Marsh, J.C.W. and Martelli, M.F. and Marti Tutusaus, J.M. and Martin, S. and Martin, M. and Martinelli, G. and Martínez-Rubio, A.M. and Martoni, A. and Maschan, A. and Maschmeyer, G. and Masszi, T. and Mazza, P. and McCann, S. and Meier, C.R. and Messina, C. and Mettivier, V. and Metzner, B. and Michallet, M. and Michieli, M. and Michon, J. and Milligan, D.W. and Milone, J.H. and Giuseppe, G.M. and Minigo, H. and Mistrik, M. and Moicean, A.D. and Monfardini, S. and Montserrat, E. and Moraleda Jimenez, J.M. and Morales-Lazaro, A. and Morandi, S. and Morra, E. and Mufti, G.J. and Musso, M. and Nagler, A. and Nalli, G. and Naparstek, E. and Narni, F. and Nenadov-Beck, M. and Neubauer, A. and Newland, A.C. and Niederwieser, D. and Niethammer, D. and Noens, L.A. and Nousiainen, T. and Novik, A. and Novitzky, N. and Occhini, D. and Odriozolas, J. and Ojanguren, J.M. and O’meara, A. and Onat, H. and Orchard, K. and Ortega, J.J. and Osieka, R. and Ossenkoppele, G.J. and Othman, B. and Ovali, E. and Ozcebe, O.I. and Ozerkan, K. and Ozturk, A. and Papatryfonos, A. and Parker, J.E. and Pastore, M. and Patrone, F. and Patton, N. and Pejin, D. and Peñarrubia, M.J. and Equiza, E.P. and Peschel, C. and Pession, A. and Pigaditou, A. and Pignon, B. and Pihkala, U. and Pimentel, P. and Pitini, V. and Podoltseva, E. and Pogliani, E.M. and Anna, A.P. and Porta, F. and Potter, M. and Powles, R. and Prentice, G.H. and Pretnar, J. and Ptushkin, V. and Quarta, G. and Reiter, A. and Remes, K. and Reykdal, S. and Santasusana, J.M.R. and Rifón, J. and Rio, B. and Rizzoli, V. and Robak, T. and Robinson, A.J. and Rodeghiero, F. and Rodríguez Fernández, J.M. and Rombos, Y. and Romeril, K.R. and Rosenmayr, A. and Rossi, J.F. and Rosti, G. and Rotoli, B. and Rowe, J.M. and Russell, N.H. and Ryzhak, O. and Rzepecki, P. and Saglio, G. and Salwender, H. and Samonigg, H. and Santoro, A. and Sanz, M.A. and Sayer, H.G. and Scanni, A. and Schaafsma, M.R. and Schaefer, U.W. and Schanz, U. and Schattenberg, A. and Schey, S.A.M. and Schlimok, G. and Schmoll, H.-J. and Schots, R. and Schouten, H. and Schwarer, A.P. and Schwerdtfeger, R. and Scimè, R. and Segel, E. and Seger, R. and Selleslag, D. and Serban, M. and Shamaa, S. and Shaw, P.J. and Siegert, W. and Siena, S. and Sierra, J. and Simonsson, B. and Singer, C.R.J. and Sirchia, G. and Skotnicki, A.B. and Slavin, S. and Snowden, J. and Sotto, J.J. and Tanyeli, A. and Tedeschi, L. and Tidefelt, U. and Tissot, J.-D. and Tobler, A. and Tomas, J.F. and Torres, J.P. and Torres, G.A. and Touraine, J.-L. and Trneny, M. and Uderzo, C. and Unal, E. and Unal, A. and Undar, L. and Urban, C. and Van den Berg, H. and van Marwijk, K.M. and Vellenga, E. and Venturini, M. and Verdonck, L.F. and Veys, P. and Vilardell, J. and Vinante, O. and Visani, G. and Vitek, A. and Vivancos, P. and Volpe, E. and Vora, A. and Vorlicek, J. and Vowels, M. and Vujic, D. and Wachowiak, J. and Wagner, T. and Wahlin, A. and Walewski, J. and Wandt, H. and Weissinger, F. and Wijermans, P.W. and Wiktor-Jedrzejczak, W. and Will, A.M. and Woell, E. and Wörmann, B. and Yaniv, I. and Yesilipek, M.A. and Yilmaz, U. and Yong, A. and Zachée, P. and Zambelli, A. and Zander, A.R. and Zintl, F. and Zoumbos, N.C. and The Acute Leukemia Working Party (ALWP) of the European Cooperative Group for Blood and Marrow Transplantation (EBMT)",
    journal = "Blood advances",
    year = "2003",
    volume = "102",
    number = "8",
    pages = "3043-3051",
    publisher = "American Society of Hematology",
    doi = "10.1182/blood-2003-03-0665",
    keywords = "acute granulocytic leukemia;  adolescent;  adult;  allogenic bone marrow transplantation;  article;  female;  HLA matching;  human;  leukemia remission;  major clinical study;  male;  mortality;  multivariate analysis;  outcomes research;  peripheral blood stem cell;  priority journal;  register;  remission;  retrospective study;  sibling;  stem cell transplantation;  survival rate;  survival time",
    abstract = "Several studies have compared bone marrow (BM) and peripheral blood (PB) as stem cell sources in patients receiving allografts, but the cell doses infused have not been considered, especially for BM. Using the ALWP/EBMT registry, we retrospectively studied 881 adult patients with acute myelocytic leukemia (AML), who received a non-T-depleted allogeneic BM (n = 515) or mobilized PB (n = 366) standard transplant, in first remission (CR1), from an HLA-identical sibling, over a 5-year period from January 1994. The BM cell dose ranged from 0.17 to 29 × 108/kg with a median of 2.7 × 108/kg. The PB cell dose ranged from 0.02 to 77 × 10 8/kg with a median of 9.3 × 108/kg. The median dose for patients receiving BM (2.7 × 108/kg) gave the greatest discrimination. In multivariate analyses, high-dose BM compared to PB was associated with lower transplant-related mortality (RR = 0.61; 95% CI, 0.39-0.98; P = .04), better leukemia-free survival (RR = 0.65; 95% CI, 0.46-0.91; P = .013), and better overall survival (RR = 0.64; 95% CI, 0.44-0. 92; P = .016). The present study in patients with AML receiving allografts in first remission indicates a better outcome with BM as compared to PB, when the dose of BM infused is rich. © 2003 by The American Society of Hematology."
}