@article{3004863,
    title = "Splenic granulomatous lesions in immunocompetent pediatric patients with visceral leishmaniasis",
    author = "Fretzayas, A. and Moustaki, M. and Kitsiou, S. and Mathioudakis, J. and Karpathios, T.",
    journal = "Scandinavian Journal of Infectious Diseases",
    year = "2001",
    volume = "33",
    number = "11",
    pages = "865-867",
    issn = "0036-5548, 1651-1980",
    doi = "10.1080/00365540110027141",
    keywords = "amphotericin B lipid complex;  antileishmanial agent;  ceftazidime;  meglumine antimonate, article;  case report;  child;  clinical feature;  drug response;  echography;  granulomatosis;  hepatomegaly;  human;  immunocompetence;  intestine injury;  male;  prognosis;  spleen injury;  splenomegaly;  treatment outcome;  visceral leishmaniasis, Antiprotozoal Agents;  Child;  Child, Preschool;  Granuloma;  Humans;  Immunocompetence;  Infant;  Leishmaniasis, Visceral;  Male;  Meglumine;  Organometallic Compounds;  Prognosis;  Splenic Diseases;  Treatment Outcome",
    abstract = "Visceral focal lesions are rarely encountered in patients with leishmaniasis despite the fact that splenomegaly, and to a lesser extent hepatomegaly, predominate among the clinical features of the disease. We present, using high resolution ultrasonography, the first 3 reported cases of focal splenic involvement in immunocompetent children with visceral leishmaniasis. All patients showed a prompt response to the conventional anti-leishmanial treatment administered. This favorable outcome indicates that localized splenic lesions should not be considered as a poor prognostic factor and that alteration of the standard anti-leishmanial regimens is not justified."
}