@article{3005753,
    title = "Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries",
    author = "Patrani, M. and Tsaganos, T. and Kotzampassi, K. and Paraschos, M. and Katsenos, C. and Giamarellos-Bourboulis, E.J. and Mandragos, K.",
    journal = "Biomarker Insights",
    year = "2016",
    volume = "21",
    number = "7",
    pages = "660-664",
    publisher = "Taylor and Francis Ltd.",
    issn = "1177-2719",
    doi = "10.3109/1354750X.2016.1171911",
    keywords = "urokinase receptor;  biological marker;  isoprotein;  urokinase receptor, adult;  Article;  bloodstream infection;  female;  Greece;  hospital admission;  human;  intensive care unit;  major clinical study;  male;  multiple organ failure;  multiple trauma;  predictive value;  protein blood level;  blood;  complication;  disease course;  multiple organ failure;  multiple trauma;  odds ratio;  sepsis, Biomarkers;  Disease Progression;  Humans;  Multiple Organ Failure;  Multiple Trauma;  Odds Ratio;  Protein Isoforms;  Receptors, Urokinase Plasminogen Activator;  Sepsis",
    abstract = "Purpose: The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas. Methods: Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset. Results: Odds ratio for trauma-associated MOF was 4.09 (p: 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 (p: 0.047) for severe sepsis. Conclusions: suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas. © 2016 Informa UK Limited, trading as Taylor & Francis Group."
}