@article{3009244,
    title = "Effects of electronic cigarette on platelet and vascular function after four months of use",
    author = "Ikonomidis, I. and Katogiannis, K. and Kostelli, G. and Kourea, K. and Kyriakou, E. and Kypraiou, A. and Tsoumani, M. and Andreadou, I. and Lambadiari, V. and Plotas, P. and Thymis, I. and Tsantes, A.E.",
    journal = "Food and Chemical Toxicology",
    year = "2020",
    volume = "141",
    publisher = "Elsevier Ireland Ltd",
    issn = "0278-6915, 1873-6351",
    doi = "10.1016/j.fct.2020.111389",
    keywords = "carbon monoxide;  malonaldehyde;  nicotine;  nicotine, adult;  arterial stiffness;  artery compliance;  Article;  blood level;  blood vessel function;  breath analysis;  carotid artery;  cigarette smoking;  controlled study;  current smoker;  female;  femoral artery;  human;  human cell;  male;  oxidative stress;  platelet aggregation assay;  pulse wave;  shear stress;  thrombocyte function;  vaping;  drug effect;  electronic cigarette;  physiology;  thrombocyte;  vascular endothelium, Blood Platelets;  Electronic Nicotine Delivery Systems;  Endothelium, Vascular;  Humans;  Nicotine",
    abstract = "We examined the effects of electronic cigarette on platelet and vascular function after 4 months of use compared to tobacco smoking. Forty smokers without cardiovascular disease were randomized to smoke either conventional cigarettes or an electronic cigarette (nicotine concentration of 12 mg/ml). At baseline and after four months, we measured a) platelet function by Platelet Function Analyzer PFA-100 and Light Transmission Aggregometry, b) pulse wave velocity, c) plasma malondialdehyde levels as oxidative stress index and d) the exhaled CO level. After 4 months, continuation of conventional cigarette smoking further impaired platelet function compared to vaping as assessed by PFA (mean increase 27.1 vs 11.6 s, p for interaction = 0.048) and by LTA (decline 24.1 vs 9.4%, p for interaction = 0.045). Conversely, compared to smoking, vaping resulted in greater reduction of exhaled CO (6.9 ppm vs 2.6, p for interaction < 0.001), improvement of PWV (decrease of 0.8 m/s vs increase of 0.8 m/s, p for interaction = 0.020) and reduction of MDA (reduction 0.13 vs increase 0.19 nmol/L, p for interaction = 0.035). Switching to electronic cigarette for 4 months has a neutral effect on platelet function while it reduces arterial stiffness and oxidative stress compared to tobacco smoking. © 2020 Elsevier Ltd"
}