@article{3009638, title = "Pyrrolizidine alkaloids from Cynoglossum columnae Ten. (Boraginaceae)", author = "Damianakos, H. and Jeziorek, M. and Sykłowska-Baranek, K. and Buchwald, W. and Pietrosiuk, A. and Chinou, I.", journal = "Phytochemistry Letters", year = "2016", volume = "15", pages = "234-237", publisher = "Elsevier Ireland Ltd", issn = "1874-3900", doi = "10.1016/j.phytol.2016.02.005", keywords = "2' epi heliosupine n oxide; 3' o acetylrinderine n oxide; 9'' methyl lithospermate; beta arbutin; drug metabolite; echinatine n oxide; plant medicinal product; pyrrolizidine alkaloid; rinderine n' oxide; rosmarinic acid; unclassified drug, Article; Boraginaceae; carbon nuclear magnetic resonance; comparative study; controlled study; Cynoglossum columnae; drug isolation; electrospray mass spectrometry; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; mass spectrometry; nonhuman; nuclear Overhauser effect; plant root; priority journal; proton nuclear magnetic resonance; tandem mass spectrometry; thin layer chromatography", abstract = "Seven secondary metabolites were isolated from the methanolic extracts of the roots and the aerial part of Cynoglossum columnae Ten. β-Arbutin and three pyrrolizidine alkaloids, namely 2′-epi-heliosupine N-oxide, rinderine N-oxide and 3′-O-acetylrinderine N-oxide were isolated from the aerial part of the plant. Echinatine N-oxide, rosmarinic acid and 9″-methyl lithospermate were isolated from the root extract. © 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved." }