@article{3020041,
    title = "Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data",
    author = "Kollias, A. and Kyriakoulis, K.G. and Rapti, V. and Trontzas, I.P. and Nitsotolis, T. and Syrigos, K. and Poulakou, G. and THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU",
    journal = "In vivo (Athens, Greece)",
    year = "2022",
    volume = "36",
    number = "1",
    pages = "361-370",
    publisher = "International Institute of Anticancer Research",
    doi = "10.21873/INVIVO.12711",
    keywords = "oxygen, female;  human;  male;  meta analysis;  middle aged;  multicenter study (topic);  prone position;  register, COVID-19;  Female;  Humans;  Male;  Middle Aged;  Multicenter Studies as Topic;  Oxygen;  Prone Position;  Registries;  SARS-CoV-2",
    abstract = "Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators’ groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=–0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19. © 2022 International Institute of Anticancer Research. All rights reserved."
}