@article{3020740,
    title = "The effects of ascorbic acid and U-74389G on renal ischemia-reperfusion injury in a rat model",
    author = "Zografos, C.G. and Chrysikos, D. and Pittaras, T. and Karampelias, V. and Chairakakis, A. and Galanos, A. and Sfiniadakis, I. and Felekouras, E. and Zografos, G.C. and Sideris, M. and Papadopoulou, K. and Papalois, A.E.",
    journal = "In vivo (Athens, Greece)",
    year = "2020",
    volume = "34",
    number = "5",
    pages = "2475-2484",
    publisher = "International Institute of Anticancer Research",
    doi = "10.21873/invivo.12063",
    keywords = "21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione;  alanine aminotransferase;  ascorbic acid;  aspartate aminotransferase;  creatinine;  gamma glutamyltransferase;  malonaldehyde;  tumor necrosis factor;  21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione;  antioxidant;  ascorbic acid;  pregnane derivative, alanine aminotransferase blood level;  animal experiment;  animal model;  animal tissue;  Article;  aspartate aminotransferase blood level;  blood sampling;  controlled study;  creatinine blood level;  drug effect;  enzyme linked immunosorbent assay;  gamma glutamyl transferase blood level;  histology;  histopathology;  kidney function;  kidney injury;  kidney ischemia;  kidney tubule;  male;  nonhuman;  rat;  renal ischemia reperfusion injury;  reperfusion;  time to treatment;  animal;  disease model;  reperfusion injury;  Wistar rat, Animals;  Antioxidants;  Ascorbic Acid;  Disease Models, Animal;  Pregnatrienes;  Rats;  Rats, Wistar;  Reperfusion Injury",
    abstract = "Background/Aim: U-74389G and ascorbic acid protect the cells from oxidation. This study aimed to depict their role in ischemia-reperfusion injury in a renal rat model. Materials and Methods: Sixty Wistars rats were randomized into six groups of 10 animals each. Group A Ischemia 30 min, reperfusion 60 min; Group B Ischemia 30 min, reperfusion 120 min; Group C Ischemia 30 min, ascorbic acid administration, reperfusion 60 min; Group D Ischemia 30 min, ascorbic acid administration, reperfusion 120 min; Group E Ischemia 30 min, U-74389G administration, reperfusion 60 min; Group F Ischemia 30 min, U-74389G administration, reperfusion 120 min. We then collected tissue and blood samples. Results: Histology and the significantly decreased malondialdehyde and tumor necrosis factor-α levels indicated that ascorbic acid was superior to U-74389G, at pre-defined time intervals. Conclusion: Ascorbic acid and U-74389G ameliorated renal damage induced by ischemia-reperfusion injury, suggesting a therapeutic effect. © 2020 International Institute of Anticancer Research. All rights reserved."
}