@article{3020742,
    title = "Clinical study of hyperglycemia and SARS-CoV-2 infection in intensive care unit patients",
    author = "ILIAS, I. and JAHAJ, E. and KOKKORIS, S. and ZERVAKIS, D. and TEMPERIKIDIS, P. and MAGIRA, E. and PRATIKAKI, M. and VASSILIOU, A.G. and ROUTSI, C. and KOTANIDOU, A. and DIMOPOULOU, I.",
    journal = "In vivo (Athens, Greece)",
    year = "2020",
    volume = "34",
    number = "5",
    pages = "3029-3032",
    publisher = "International Institute of Anticancer Research",
    doi = "10.21873/invivo.12136",
    keywords = "glucose;  short acting insulin;  insulin, adult;  Article;  artificial ventilation;  blood glucose monitoring;  clinical article;  clinical trial;  coronavirus disease 2019;  critical illness;  critically ill patient;  disease course;  female;  glucose blood level;  hospital mortality;  human;  hyperglycemia;  hypoxemia;  insulin treatment;  length of stay;  male;  medical intensive care unit;  nonhuman;  respiratory failure;  Severe acute respiratory syndrome coronavirus 2;  stress;  Betacoronavirus;  complication;  Coronavirus infection;  diabetes mellitus;  genetics;  hospitalization;  hyperglycemia;  intensive care unit;  metabolism;  middle aged;  pandemic;  pathogenicity;  pathophysiology;  respiratory failure;  severe acute respiratory syndrome;  virology;  virus pneumonia, Betacoronavirus;  Blood Glucose;  Coronavirus Infections;  Diabetes Mellitus;  Female;  Hospitalization;  Humans;  Hyperglycemia;  Insulin;  Intensive Care Units;  Male;  Middle Aged;  Pandemics;  Pneumonia, Viral;  Respiration, Artificial;  Respiratory Insufficiency;  Severe Acute Respiratory Syndrome",
    abstract = "Background/Aim: Reports indicate that coronaviridae may inhibit insulin secretion. In this report we aimed to describe the course of glycemia in critically ill patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Patients and Methods: We studied 36 SARS-CoV-2 patients (with no history of diabetes) in one intensive care unit (ICU). All the patients were admitted for hypoxemic respiratory failure; all but four required mechanical ventilation. The mean (±SD) age of the patients was 64.7 (9.7) years; 27 were men; the mean (±SD) duration of ICU stay was 12.9 (8.3 days). Results: Twenty of 36 patients presented with hyperglycemia; brief intravenous infusions of short-acting insulin were administered in six patients. As of May 29 2020, 11 patients had died (seven with hyperglycemia). In 17 patients the Hyperglycemia Index [HGI; defined as the area under the curve of (hyper)glycemia level time (h) divided by the total time in the ICU] was <16.21 mg/dl (0.90 mmol/l), whereas in three patients the HGI was ≥16.21 mg/dl (0.90 mol/l) and <32.25 mg/dl (1.79 mmol/l). Conclusion: In our series of ICU patients with SARS-CoV-2 infection, and no history of diabetes, a substantial number of patients had hyperglycemia, to a higher degree than would be expected by the stress of critical illness, lending credence to reports that speculated a tentative association between SARS-CoV-2 and hyperglycemia. This finding is important, since hyperglycemia can lead to further infectious complications. © 2020 International Institute of Anticancer Research. All rights reserved."
}