@article{3020744,
    title = "Nuchal-type fibroma: Single-center experience and systematic literature review",
    author = "Kostakis, I.D. and Feretis, T. and Damaskos, C. and Garmpis, N. and Liapis, G. and Pateras, I. and Garmpi, A. and Georgakopoulou, V.E. and Antoniou, E.A.",
    journal = "In vivo (Athens, Greece)",
    year = "2020",
    volume = "34",
    number = "5",
    pages = "2217-2223",
    publisher = "International Institute of Anticancer Research",
    doi = "10.21873/invivo.12032",
    keywords = "adult;  Article;  case report;  clinical article;  contrast enhancement;  data base;  excision;  female;  fibroma;  histopathology;  human;  human cell;  immunohistochemistry;  male;  middle aged;  muscle;  nape;  nuclear magnetic resonance imaging;  splenius muscle;  systematic review;  trapezius muscle;  tumor volume;  young adult;  differential diagnosis;  Gardner syndrome;  genetics;  head and neck tumor;  neck;  tumor recurrence, Adult;  Diagnosis, Differential;  Female;  Fibroma;  Gardner Syndrome;  Head and Neck Neoplasms;  Humans;  Male;  Middle Aged;  Neck;  Neoplasm Recurrence, Local;  Young Adult",
    abstract = "Background: Nuchal-type fibroma is a rare benign tumor arising from the connective tissue. Our aim was to present our experience via two cases of this tumor and a comprehensive review of the literature. Patients and Methods: We report a case of a 23-year-old female with a mass located in the posterior neck and the upper back and a case of a 50-year-old male with a mass located in the posterior neck, which were proved to be nuchal-type fibromas in the histopathological examination. We also searched the PubMed/Medline database for published cases of nuchal-type fibromas. Results and Discussion: Nuchaltype fibroma is a rare benign tumor arising from the connective tissue, usually in the posterior neck, which affects different ages, with most patients being male. It is a poorly circumscribed tumor consisting of hypocellular, thick, dense and haphazardly arranged collagen bundles with entrapped adipocytes, nerve fibers and muscle fascicles and a few scattered spindle cells, which are CD34 positive. Its excision is curative, and the recurrence risk is generally low. However, patients with Gardner's syndrome may experience recurrence more frequently. Conclusion: Nuchal-type fibroma should be included in the differential diagnosis of subcutaneous, soft-tissue masses, especially when these involve the posterior neck. © 2020 International Institute of Anticancer Research. All rights reserved."
}