@article{3021261,
    title = "Synthesis of diphenoxyadamantane alkylamines with pharmacological interest",
    author = "Georgiadis, M.-O. and Kourbeli, V. and Ioannidou, V. and Karakitsios, E. and Papanastasiou, I. and Tsotinis, A. and Komiotis, D. and Vocat, A. and Cole, S.T. and Taylor, M.C. and Kelly, J.M.",
    journal = "Bioorganic and Medicinal Chemistry Letters",
    year = "2019",
    volume = "29",
    number = "11",
    pages = "1278-1281",
    publisher = "Elsevier Ireland Ltd",
    doi = "10.1016/j.bmcl.2019.04.010",
    keywords = "aliphatic amine;  antitrypanosomal agent;  diphenoxyadamantane alkylamine;  tuberculostatic agent;  unclassified drug;  adamantane;  amine;  antitrypanosomal agent;  tuberculostatic agent, antibacterial activity;  Article;  bacterial growth;  controlled study;  drug structure;  drug synthesis;  growth inhibition;  Mycobacterium tuberculosis;  nonhuman;  trypanocidal activity;  Trypanosoma brucei;  chemical structure;  chemistry;  dose response;  drug effect;  drug sensitivity;  structure activity relation;  synthesis;  Trypanosoma brucei brucei, Adamantane;  Amines;  Antitubercular Agents;  Dose-Response Relationship, Drug;  Molecular Structure;  Mycobacterium tuberculosis;  Parasitic Sensitivity Tests;  Structure-Activity Relationship;  Trypanocidal Agents;  Trypanosoma brucei brucei",
    abstract = "In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia–f and IIa–f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity. © 2019 Elsevier Ltd"
}