@article{3021279,
    title = "DAB2IP expression in abdominal aortic aneurysm: EZH2 and miR-363-3p as potential mediators",
    author = "Legaki, E. and Klonaris, C. and Athanasiadis, D. and Patelis, N. and Sioziou, A. and Liakakos, T. and Gazouli, M.",
    journal = "In vivo (Athens, Greece)",
    year = "2019",
    volume = "33",
    number = "3",
    pages = "737-742",
    publisher = "International Institute of Anticancer Research",
    doi = "10.21873/invivo.11533",
    keywords = "antithrombocytic agent;  cholesterol;  disabled homolog 2 interacting protein;  hydroxymethylglutaryl coenzyme A reductase inhibitor;  messenger RNA;  microRNA;  microRNA 363 3p;  protein;  transcription factor EZH2;  triacylglycerol;  unclassified drug;  biological marker;  DAB2IP protein, human;  EZH2 protein, human;  guanosine triphosphatase activating protein;  microRNA;  MIRN363 microRNA, human;  transcription factor EZH2, abdominal aortic aneurysm;  aged;  Article;  clinical article;  comparative study;  controlled study;  diabetes mellitus;  down regulation;  female;  human;  human tissue;  hypertension;  male;  mRNA expression level;  polymerase chain reaction;  protein expression;  regulator gene;  RNA analysis;  smoking;  upregulation;  abdominal aortic aneurysm;  comorbidity;  gene expression;  gene expression regulation;  genetics;  metabolism;  pathology;  RNA interference;  very elderly, Aged;  Aged, 80 and over;  Aortic Aneurysm, Abdominal;  Biomarkers;  Comorbidity;  Enhancer of Zeste Homolog 2 Protein;  Female;  Gene Expression;  Gene Expression Regulation;  Humans;  Male;  MicroRNAs;  ras GTPase-Activating Proteins;  RNA Interference",
    abstract = "Background/Aim: Nine genetic loci have been associated with abdominal aortic aneurysm (AAA) susceptibility, including DAB2IP. This gene is playing a role in apoptosis, cell proliferation and epithelial–to–mesenchymal transition in cancers. This study aimed to elucidate the differential expression levels of DAB2IP in AAA tissues and investigate whether mir-363-3p and EZH2 can be considered as potential mediators of its expression. Materials and Methods: 18 AAA samples and 15 non-aneurysmatic controls were collected. Relative mRNA expression levels of DAB2IP, EZH2 and mir-363-3p were measured using qPCR. Results: DAB2IP was significant up-regulated (~2.29 fold) in AAA tissues, while EZH2 and mir-363-3p were down-regulated (3.28 and 3.62-fold, respectively). A limited negative correlation was found between the DAB2IP and EZH2 expression and between DAB2IP and the mir-363-3p. Conclusion: An increased expression of DAB2IP in AAA tissues was shown. We suggest 2 potential mediators of DAB2IP expression in abdominal aortic aneurysm, EZH2 and mir-363-3p. © 2019 International Institute of Anticancer Research. All rights reserved."
}